2. Immunology/Inflammation
  3. Interleukin Related
  4. QX008N

QX008N 是一种人源化 IgG1 单克隆抗体，同时也是 TSLP 抑制剂，KD 为 0.0175 nM。QX008N 通过抑制 TSLP-TSLPR-IL-7Rα 的相互作用阻断 TSLP 诱导的信号通路。QX008N 可降低嗜酸性粒细胞和 IgE 水平、改善肺功能、阻断 TSLP 诱导的炎症，与抗 IL-4R 抗体联合给药时还能增强对炎症介质的抑制作用。QX008N 可用于哮喘的相关研究。

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QX008N

QX008N Chemical Structure

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QX008N 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

QX008N is a humanized IgG1 monoclonal antibody and also a TSLP inhibitor with a KD value of 0.0175 nM. QX008N blocks TSLP-induced signaling pathways by inhibiting the interaction of TSLP-TSLPR-IL-7Rα. QX008N reduces eosinophil and IgE levels, improves pulmonary function, blocks TSLP-induced inflammation, and enhances the inhibitory effect on inflammatory mediators when administered in combination with anti-IL-4R antibodies. QX008N is applicable to relevant research on asthma[1][2].

反应种属

Human
IC50 & Target[1]

IL7R

 

体外研究
(In Vitro)

QX008N 以高亲和力结合人源 TSLP (Kd = 0.0175 nM)，该亲和力优于 Tezepelumab (HY-P99366A) 类似物[1]。
QX008N (2 μg/mL initial concentration, 1:5 gradient dilutions) 可特异性结合人、食蟹猴、恒河猴的 TSLP[1]。
QX008N 可强效抑制人源 TSLP 与 TSLPR-IL-7Rα 复合物之间的相互作用[1]。
QX008N (2 μg/mL initial concentration, 1:3 gradient dilutions) 可强效中和经重组人源、天然人源或重组食蟹猴源 TSLP 处理的 SW756-STAT5-Luciferase 细胞中由 TSLP 诱导的 JAK/STAT 信号通路[1]。
QX008N (10 concentration points via 1:5 gradient dilutions) 可强效抑制人 TSLP 诱导的人外周血单个核细胞 (PBMC) 中 CCL17 的分泌 (IC50 = 9.836 ng/mL) 及全血中 CCL17 的分泌 (IC50 = 1.599 ng/mL)，同时抑制人 PBMC 中 CCL22 的分泌，其活性优于 Tezepelumab 类似物[1]。
QX008N 与抗 IL-4R 抗体 Oturkibart (HY-P991152) 联合使用时，可强效抑制经 TSLP、IL-4、IL-13 和 IL-33 刺激的人 PBMC 中 CCL17 的产生，抑制率达 95.5%，超过单药治疗的叠加效应[1]。
QX008N (孵育 6 天) 与抗 IL-4R 抗体 QX005N 联合使用时，相较于 QX008N 单药治疗，在由 MRC-5 成纤维细胞、A549 上皮细胞和人 PBMC 组成的三元培养模型中，对 OVA 诱导的 CCL17、IL-5 和 CCL26 产生的抑制作用更强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

QX008N 相关抗体:
体内研究
(In Vivo)

QX008N (10-50 mg/kg；每周 1 次；共 6 剂；皮下注射) 在食蟹猴哮喘模型中呈剂量依赖性地改善肺功能、降低外周血和支气管肺泡灌洗液中的炎症标志物水平，并减少嗜酸性粒细胞浸润[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkey (male, 3-6 years, 2.5-7.0 kg, sensitized via intraperitoneal injection of Ascaris suis extract mixed with Al(OH)3 adjuvant at weeks 1, 2, and 3, followed by nebulized allergen challenge at weeks 4-7)[1]
Dosage: 10 mg/kg; 50 mg/kg
Administration: once weekly; 6 doses; subcutaneous injection
Result: Decreased percentage change in airway resistance by 25% and increased percentage change in lung dynamic compliance by 20% at one week after three 10 mg/kg doses.
Reduced peripheral blood specific IgE by ~38% after three 10 mg/kg doses and TSLP by ~42% after six 10 mg/kg doses.
Decreased percentage change in airway resistance by 42.4% and increased percentage change in lung dynamic compliance by 30% at one week after first 50 mg/kg dose.
Reduced peripheral blood TSLP by ~66% and specific IgE by ~62% after first 50 mg/kg dose.
Lowered TSLP levels, eosinophil counts and eosinophil percentage in bronchoalveolar lavage fluid at 10 mg/kg and 50 mg/kg.
Attenuated eosinophil infiltration in lung tissue at 10 mg/kg and 50 mg/kg.
Reached plasma concentration of 336.3 μg/mL after first 50 mg/kg dose.
基因 ID

85480  [NCBI]

Accession

Q969D9-1
靶点

TSLP
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
组分

Please refer to the lot-specific COA for specific buffer information.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

QX008N 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QX008NInterleukin RelatedILIgEhuman PBMCsasthmaJAK/STAT signalingcynomolgus monkeySW756-STAT5-Luciferase cellssevere asthmaeosinophilTSLPR-IL-7RαTSLPInhibitorinhibitorinhibit

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目录号：
HY-P992447
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