2. MAPK/ERK Pathway Apoptosis Immunology/Inflammation
  3. p38 MAPK TNF Receptor Interleukin Related
  4. R-03201195

R-03201195 是一种高效的、具有选择性的 p38 MAP 激酶抑制剂，其对 p38α 的 IC50 为 0.7 nM。R-03201195 对 THP-1 细胞 TNF-α、人全血 IL-1β 具有抑制活性，其 IC50 分别为 0.25 和 0.57 nM。R-03201195 可用于类风湿性关节炎等炎症性疾病。

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R-03201195

R-03201195 Chemical Structure

CAS No. : 249936-55-8

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R-03201195 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

R-03201195 is an efficient and selective p38 MAP kinase inhibitor with an IC50 for p38α of 0.7 nM. R-03201195 has inhibitory activity against TNF-α in THP-1 cells and against IL-1β in human whole blood, with IC50 values of 0.25 and 0.57 nM respectively. R-03201195 can be used for inflammatory diseases such as rheumatoid arthritis[1].

IC50 & Target[1]

p38 MAP kinase

 

IL-1β

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
THP-1 IC50
0.25 μM
Compound: 63
Inhibition of LPS-induced TNFalpha production in THP1 cells
Inhibition of LPS-induced TNFalpha production in THP1 cells
[PMID: 16509574]
THP-1 IC50
250 nM
Compound: Ro-3201195
Inhibition of p38alpha-induced TNFalpha production in human THP1 cells
Inhibition of p38alpha-induced TNFalpha production in human THP1 cells
[PMID: 18539026]
分子量

371.36

Formula

C19H18FN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

R-03201195 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R-03201195249936-55-8R03201195R 03201195p38 MAPKTNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILp38 MAP kinaseselective inhibitorRO3201195orally bioavailableinflammationTNF-α inhibitionkinase selectivitycrystal structurepharmacokineticsrheumatoid arthritisInhibitorinhibitorinhibit

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产品名称：
R-03201195
目录号：
HY-18794
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