2. Others Neuronal Signaling GPCR/G Protein
  3. Drug Isomer Drug Derivative 5-HT Receptor
  4. (R)-LY-41

(R)-LY-41 是 LY-41 (HY-165624) 的 R 型对映体，是 2-Sminotetralin (HY-W022362) 的衍生物也是 8-OH-DPAT (HY-112061) 的类似物。(R)-LY-41 是一种强效且选择性的 5-羟色胺 1A 受体 (5-HT1A receptor) 激动剂。(R)-LY-41 能够减少脱羧酶抑制剂 (NSD 1015) 诱导的大鼠脑中 5-羟色氨酸 (5-HT 合成的前体) 的积累。(R)-LY-41 可降低大鼠体温，并抑制其离笼反应。(R)-LY-41 能诱发 5-羟色胺行为综合征，但其作用弱于 (S)-LY-41 (HY-165624A)。(R)-LY-41 可用于神经系统疾病的研究，如抑郁症和焦虑症。

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(R)-LY-41

(R)-LY-41 Chemical Structure

CAS No. : 136296-43-0

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(R)-LY-41 相关抗体

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查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (R)-LY-41 is a potent and selective 5-HT1A receptor agonist. (R)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (R)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (R)-LY-41 can induce the 5-HT behavioral syndrome but is weaker than (S)-LY-41 (HY-165624A). (R)-LY-41 can be used for the research of neurological disease, such as depression and anxiety[1].

IC50 & Target[1]

5-HT1A Receptor

 

分子量

273.41

Formula

C18H27NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-LY-41 相关分类

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Keywords:

(R)-LY-41136296-43-0Drug IsomerDrug Derivative5-HT ReceptorDrug derivativeSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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