2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Ramiprilat acyl-β-D-glucuronide

Ramiprilat acyl-β-D-glucuronide 是 Ramiprilat (HY-B0279) 的酰基葡萄糖醛酸苷代谢物。Ramiprilat acyl-β-D-glucuronide 在使用强阳离子交换柱进行固相萃取的过程中，其葡萄糖醛酸部分会发生甲基化，形成甲基化衍生物。Ramiprilat acyl-β-D-glucuronide 在质谱分析中会发生源内转化生成 Ramiprilat，转化程度与去簇电压成正比。

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Ramiprilat acyl-β-D-glucuronide

Ramiprilat acyl-β-D-glucuronide Chemical Structure

CAS No. : 1357570-22-9

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Ramiprilat acyl-β-D-glucuronide 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ramiprilat acyl-β-D-glucuronide is an acyl glucuronide metabolite of Ramiprilat (HY-B0279). Ramiprilat acyl-β-D-glucuronide undergoes methylation on its glucuronic acid moiety during solid phase extraction with strong cation exchanger cartridges, forming a methylated derivative. Ramiprilat acyl-β-D-glucuronide undergoes in-source conversion to Ramiprilat in mass spectrometry, with conversion extent proportional to declustering potential voltage[1].

体外研究
(In Vitro)

Ramiprilat acyl-β-D-glucuronide (10.00-100.00 μg/mL) 在初始反相 HPLC 条件下可与雷米普利拉实现色谱分离，不会通过源内转化导致雷米普利拉的定量变异性，且在采用强阳离子交换剂固相萃取处理时会发生 65% 的损失，同时形成甲基化衍生物[1]。
Ramiprilat acyl-β-D-glucuronide (10.00-100.00 μg/mL) 在蛋白沉淀法样品制备的蒸发过程中会发生水解；与 50°C 相比，35°C 的蒸发温度下观察到水解程度降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ramiprilat acyl-β-D-glucuronide 相关抗体:
分子量

564.58

Formula

C27H36N2O11
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ramiprilat acyl-β-D-glucuronide 相关分类

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  • 稀释计算器

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Keywords:

Ramiprilat acyl-β-D-glucuronide1357570-22-9Drug Metaboliteglucuronic acid moietymass spectrometryramiprilatbioanalytical methodmethylated derivativereversed-phase HPLCprotein precipitationsolid-phase extractionacyl glucuronide metabolitestrong cation exchanger cartridgesInhibitorinhibitorinhibit

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