2. Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. VEGFR PD-1/PD-L1
  4. RC148

RC148 是一种人源化 IgG1 双特异性抗体，靶向 VEGF 和 PD-1。RC148 可促进二聚体 VEGF 交联，并逐步增强 PD-1 的结合活性，从而降低抗 VEGF 途径的全身毒性，并通过 VEGF 诱导的肿瘤区域富集增强抗肿瘤效力。RC148 可阻断 VEGF 与 VEGFR 以及 PD-1 与 PD-L1 的结合，抑制人脐静脉内皮细胞的增殖和迁移，并促进 T 细胞的有效活化。RC148 可用于乳腺癌和肺癌的研究。

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RC148

RC148 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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RC148 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RC148 is a humanized IgG1 bispecific antibody targeting VEGF and PD-1. RC148 allows dimeric VEGF crosslinking and gradually enhances PD-1 binding activity, potentially reduces systemic toxicity of the anti-VEGF approach, and enhances antitumor potency via VEGF-triggered enrichment in tumor areas. RC148 blocks the binding of VEGF to VEGFR and PD-1 to PD-L1, prevents the growth and migration of human umbilical vein endothelial cells, and enables efficient T cell activation. RC148 can be used for the study of breast cancer and lung cancer[1].

反应种属

Human
基因 ID

29126  [NCBI] & 7422  [NCBI]

Accession
靶点

PD-1 & VEGF
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RC148 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RC148RC 148RC-148VEGFRPD-1/PD-L1Vascular endothelial growth factor receptorPD-1/Programmed death-ligand 1IgG1VEGFPD-1Inhibitorinhibitorinhibit

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产品名称：
RC148
目录号：
HY-P991739
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