ANGPTL7/Angiopoietin-related 7 蛋白, Human (Biotinylated, HEK293, mFc-Avi)

ANGPTL7/angiopoietin-related 7 protein plays a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it serves as a mediator for dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue that studies have shown is necessary for aqueous humor outflow and maintenance of intraocular pressure. ANGPTL7/Angiopoietin-related 7 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived ANGPTL7/Angiopoietin-related 7 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of ANGPTL7/Angiopoietin-related 7 Protein, Human (Biotinylated, HEK293, mFc-Avi) is 320 a.a., with molecular weight of ~66 kDa.

ANGPTL7/血管生成素相关 7 蛋白在细胞外基质的形成和组织中发挥着至关重要的作用。特别是在眼睛中，它充当地塞米松诱导的小梁网内基质沉积的介质，小梁网是眼房水流出和维持眼内压所必需的组织。此外，研究结果表明，ANGPTL7 作为角膜血管生成的负调节因子，在保持角膜无血管和透明度方面发挥着重要作用。在结构上，它通过二硫键形成同源四聚体，进一步强调了其在维持眼组织细胞外基质结构完整性方面的作用。

Immobilized Human LILRB2 Fc at 5 μg/mL (100 μL/well) can bind Biotinylated Human ANGPTL7 mFc-Avi with a linear range of 0.156-2.5 μg/mL.

Human

HEK293

C-Avi;C-mFc

O43827 (Q27-P346)

10218  [NCBI]

Approximately 66 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of Tris with Glycine, Arginine and NaCl, pH 7.5. Normally trehalose is added as protectant before lyophilization.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.