Plasminogen 蛋白, Human

Plasminogen protein is the key precursor of plasmin and plays a central role in a variety of physiological and pathological processes. Plasmin is derived from plasminogen and dissolves fibrin during blood coagulation, affecting embryonic development, tissue remodeling, tumor invasion and inflammation. Plasminogen Protein, Human is the recombinant human-derived Plasminogen protein, expressed by E. coli , with tag free.

纤溶酶原蛋白在多种生理和病理过程中发挥着至关重要的作用，是纤溶酶的前体，纤溶酶是一种具有多方面活性的有效蛋白水解因子。纤溶酶的主要功能涉及溶解血栓中的纤维蛋白，有助于胚胎发育、组织重塑、肿瘤侵袭和炎症等过程。它在排卵期间削弱 Graafian 卵泡壁并激活各种酶，包括尿激酶型纤溶酶原激活剂、胶原酶和补体酶原（如 C1 和 C5）。纤溶酶的蛋白水解作用延伸至裂解纤连蛋白、层粘连蛋白、纤维蛋白、血小板反应蛋白和血管性血友病因子，导致细胞脱离和细胞凋亡。它参与组织重塑和肿瘤侵袭可能受到 CSPG4 的调节。纤溶酶原也与细胞结合，衍生的血管抑制素充当血管生成抑制剂，阻断新血管形成并阻碍体内实验性原发性和转移性肿瘤的生长。纤溶酶原的多种作用强调了其在协调复杂的细胞和生理过程中的重要性。

Measured by its binding ability in a functional ELISA. Immobilized Human Plasminogen at 2 μg/mL can bind Anti-Plasminogen antibody. The ED₅₀ for this effect is 18.12 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Human Plasminogen at 2 μg/mL can bind Anti-Plasminogen antibody. The ED₅₀ for this effect is 18.12 ng/mL.

Human

E. coli

Tag Free

P00747 (V98-P356)

5340  [NCBI]

Partial

VYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSP

Approximately 35 kDa, based on SDS-PAGE under reducing conditions.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm solution of 20 mM NaAc, 4 % Mannitol, pH 5.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in sterile distilled water.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.