2. Anti-infection
  3. Bacterial
  4. Retro-1

Retro-1 是一种毒素抑制剂。Retro-1 可阻断 STxB 向反式高尔基网络/高尔基体的逆向运输。Retro-1 可抑制 Ricin、细菌毒素 Stx1 和 Stx2 对细胞的毒性作用。Retro-1 还可以显著增强反义寡核苷酸和剪接转换寡核苷酸的有效性。

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Retro-1

Retro-1 Chemical Structure

CAS No. : 313683-81-7

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Retro-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Retro-1 is a toxin inhibitor. Retro-1 blocks the retrograde transport of STxB to the trans-Golgi network/Golgi. Retro-1 inhibits the cytotoxic effects of Ricin, bacterial toxins Stx1 and Stx2. Retro-1 can also substantially enhance the effectiveness of antisense and splice switching oligonucleotides[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa EC50
6.2 μM
Compound: Retro-1; 6, mixture of enantiomers, mixture of conformers (1:1)
Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in radiolabelled-methionine incorporation preincubated with cells for 20 mins followed by Stx1 addition and measured after 1 hr by scintillation counting analysis
Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in radiolabelled-methionine incorporation preincubated with cells for 20 mins followed by Stx1 addition and measured after 1 hr by scintillation counting analysis
[PMID: 32648758]
分子量

373.24

Formula

C18H17BrN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Retro-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Retro-1313683-81-7Retro1Retro 1BacterialA549HeLaMiceAnti-toxicASOInhibitorinhibitorinhibit

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