2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Rezivertinib hydrochloride

Rezivertinib hydrochloride  (Synonyms: BPI-7711 hydrochloride)

目录号: HY-109189A
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Rezivertinib (BPI-7711) hydrochloride 是一种口服有效，高选择性和不可逆的第三代 EGFR 酪氨酸激酶抑制剂 (TKI)。Rezivertinib hydrochloride 对常见的激活 EGFR 和抗性T790M 突变具有高效力。Rezivertinib hydrochloride 具有出色的透过中枢神经系统 (CNS) 能力，并具有抗肿瘤活性，例如非小细胞肺癌 (NSCLC)。

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Rezivertinib hydrochloride

Rezivertinib hydrochloride Chemical Structure

CAS No. : 2170255-78-2

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Rezivertinib hydrochloride 的其他形式现货产品:

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Rezivertinib hydrochloride 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Rezivertinib (BPI-7711) hydrochloride is an orally active, highly selective and irreversible third-generation EGFR tyrosine kinase inhibitor (TKI). Rezivertinib hydrochloride exhibits high potency against the common activation EGFR and the resistance T790M mutations. Rezivertinib hydrochloride has excellent central nervous system (CNS) penetration and has antitumor activity, such as non-small cell lung cancer (NSCLC)[1][2].

体外研究
(In Vitro)

Rezivertinib (BPI-7711) hydrochloride 选择性抑制细胞系中 EGFR 突变的细胞增殖：GI50 为 13.3 nM (PC9，del19)，6.8 nM (HCC827，L858R)，22 nM (NCI-H1975，del19) /T790M) 和 > 1000 nM (A431，EGFR WT)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rezivertinib hydrochloride 相关抗体:
体内研究
(In Vivo)

Rezivertinib (BPI-7711；6.25-25 mg/kg/天；口服；14 天) hydrochloride 显示显著的肿瘤消退[2]。
Rezivertinib (12.5 mg/kg/天；口服；14 天) hydrochloride 在 H1975-luc 人 NSCLC 小鼠模型中的存活时间平均延长 112%[2]。
Rezivertinib (50 mg/kg/天；口服) hydrochloride 具有抗肿瘤功效，与提高动物平均总生存期 115% (28 天对 13 天) 相关[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

523.03

Formula

C27H31ClN6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Rezivertinib hydrochloride 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rezivertinib2170255-78-2BPI-7711BPI7711BPI 7711EGFREpidermal growth factor receptorErbB-1HER1EGFR InhibitorNSCLCorally activeirreversible third-generationInhibitorinhibitorinhibit

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