2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. S 15931

S 15931 是一种 5-HT1A 受体抑制剂。S 15931 可抑制小家鼠福尔马林诱导的后爪舔舐晚期阶段反应，醋酸诱导的腹部扭体反应。S 15931 可消除褐家鼠 8-OH-DPAT 诱导的自发性甩尾反应，增强吗啡的镇痛作用。S 15931 可用于疼痛相关研究。

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S 15931

S 15931 Chemical Structure

CAS No. : 153607-45-5

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S 15931 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S 15931 is a 5-HT1A receptor inhibitor. S 15931 inhibits the late-phase hindpaw licking response induced by formalin and the abdominal writhing response induced by acetic acid in Mus musculus. S 15931 abolishes the spontaneous tail-flick response induced by 8-OH-DPAT in Rattus norvegicus and potentiates the analgesic effect of morphine. S 15931 is applicable for pain-related research[1].

体内研究
(In Vivo)

S 15931 (40 mg/kg；皮下注射；单次给药；测试前 30 分钟) 对雄性 NMRI 小鼠福尔马林诱导舔舐反应的晚期阶段的抑制效力强于早期阶段[1]。
S 15931 (40 mg/kg；皮下注射；单次给药；测试前 30 分钟) 可抑制雄性 NMRI 小鼠的醋酸诱导扭体反应[1]。
S 15931 (40 mg/kg；皮下注射；单次给药；测试前 30 分钟) 可诱导雄性 NMRI 小鼠出现转棒共济失调[1]。
S 15931 (40 mg/kg；皮下注射；单次给药；于 8-OH-DPAT 给药前 20 分钟给药) 可强效抑制雄性 Wistar 大鼠中由 8-OH-DPAT (HY-112061) 诱导的自发性甩尾反应[1]。
S 15931 (0-10.0 mg/kg；皮下注射；单次给药；测试前 60 分钟) 本身不会改变发声阈值，但在雄性 Wistar 大鼠的电刺激尾部发声试验中，可呈剂量依赖性增强吗啡的镇痛作用，当剂量≥0.63 mg/kg 时效果显著[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI (male, 20-25 g, formalin-induced hindpaw licking model)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; single dose; 30 minutes pre-test
Result: Achieved an ID50 of 1.2 mg/kg for inhibition of the early phase of formalin-induced licking, producing a 95% maximum observed effect at 40.0 mg/kg.
Achieved an ID50 of 0.3 mg/kg for inhibition of the late phase of formalin-induced licking, producing a 99% maximum observed effect at 40.0 mg/kg.
Animal Model: NMRI (male, 20-25 g, acetic acid-induced abdominal writhing model)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; single dose; 30 minutes pre-test
Result: Achieved an ID50 of 10.4 mg/kg for inhibition of acetic acid-induced writhing, producing a 93% maximum observed effect at 40.0 mg/kg.
Animal Model: NMRI (male, 20-25 g, rotarod ataxia model)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; single dose; 30 minutes pre-test
Result: Achieved an ID50 of 21.3 mg/kg for induction of rotarod ataxia, producing a 90% maximum observed effect at 40.0 mg/kg.
Animal Model: Wistar (male, 200-250 g, 8-OH-DPAT-induced spontaneous tail-flicks model)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; single dose; 20 minutes pre-8-OH-DPAT
Result: Achieved an ID50 of 0.7 mg/kg for inhibition of 8-OH-DPAT-induced spontaneous tail-flicks, producing a 99% maximum observed effect at 40.0 mg/kg.
Animal Model: Wistar (male, 200-250 g, electrical tail stimulation vocalization model)[1]
Dosage: 0.01, 0.04, 0.16, 0.83, 2.5, 10.0 mg/kg
Administration: s.c.; single dose; 60 minutes pre-test
Result: Did not significantly alter vocalization threshold relative to vehicle when administered alone.
Dose-dependently facilitated morphine's antinociceptive action, with significant potentiation observed at doses of 0.63 mg/kg, 2.5 mg/kg, and 10.0 mg/kg when co-administered with morphine.
分子量

364.48

Formula

C23H28N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

S 15931 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S 15931153607-45-5S15931S-159315-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptormale NMRI micemorphineratsantinociceptionacetic acid-induced abdominal writhing8-OH-DPAT-induced spontaneous tail-flicksformalin-induced hindpaw lickingataxia5-HT1A receptormiceInhibitorinhibitorinhibit

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目录号：
HY-182584
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