2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. S-8666

S-8666 是一种口服有效的尿酸排泄性降压利尿剂。S-8666 具有 S-(-)- 和 R-(+)- 两种异构体，其利尿和排钠活性完全由 S-(-)- 异构体主导，而 R-(+)- 异构体则无明显活性。S-8666 依赖于有机酸转运系统经近端肾小管分泌。S-8666 在多种动物 (如大鼠和黑猩猩) 中均表现出明显的促尿酸排泄活性和利尿作用。

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S-8666

S-8666 Chemical Structure

CAS No. : 103968-87-2

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S-8666 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S-(-)- and R-(+)-isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S-(-)-isomer, while the R-(+)-isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees)[1][2].

分子量

340.18

Formula

C11H11Cl2NO5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

S-8666 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-8666103968-87-2S8666S 8666Endogenous Metaboliteenantioselectivitydiuretic activityrenal excretionstop-flow analysisInhibitorinhibitorinhibit

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目录号：
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