2. Apoptosis Immunology/Inflammation
  3. Necroptosis NO Synthase
  4. (rel)-Salcolin A

(rel)-Salcolin A 是一种黄酮木脂素类化合物，具有抗癌、抗炎和神经保护活性。(rel)-Salcolin A 对间变性甲状腺癌细胞 (HTH83)、乳头状甲状腺癌细胞 (TPC1) 的 IC50 分别 66.69 μM 和 56.12 μM。(rel)-Salcolin A 还抑制 LPS 诱导 NO 产生，IC50 为 14.65 μM。(rel)-Salcolin A 通过诱导甲状腺癌细胞坏死 (Necroptosis)、抑制炎症因子 NO 生成、保护谷氨酸诱导的神经细胞损伤，神经保护的 EC50 为 47.44 μM。(rel)-Salcolin A 可用于甲状腺癌、抗炎及神经保护相关研究。(rel)-Salcolin A 能够从 Casearia arborea (乔木脚骨脆) 的叶子和 Zea mays (玉米) 的茎中天然提取得到。

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(rel)-Salcolin A

(rel)-Salcolin A Chemical Structure

CAS No. : 1977557-69-9

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生物活性

(rel)-Salcolin A is a flavonoid lignan compound with anticancer, anti-inflammatory, and neuroprotective activities. (rel)-Salcolin A has IC50 values ??of 66.69 μM and 56.12 μM against anaplastic thyroid carcinoma cells (HTH83) and papillary thyroid carcinoma cells (TPC1), respectively. (rel)-Salcolin A also inhibits LPS-induced NO production with an IC50 of 14.65 μM. (rel)-Salcolin A exerts its effects by inducing necroptosis in thyroid cancer cells, inhibiting the production of the inflammatory factor NO, and protecting against glutamate-induced neuronal cell damage, with a neuroprotective E50 of 47.44 μM. (rel)-Salcolin A can be used in research related to thyroid cancer, anti-inflammation, and neuroprotection. (rel)-Salcolin A can be naturally extracted from the leaves of Casearia arborea and the stems of Zea mays (corn)[1][2].

分子量

526.49

Formula

C27H26O11
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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Keywords:

(rel)-Salcolin A1977557-69-9NecroptosisNO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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