2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Sameridine

Sameridine  (Synonyms: 沙美利定; NIH 10908 free base)

目录号: HY-105525
产品使用指南 技术支持

Sameridine (NIH-10908) 是μ-阿片受体的弱部分激动剂。鞘内注射 Sameridine 可产生局部麻醉和镇痛作用。低剂量 Sameridine 对呼吸抑制作用极小，但高剂量可抑制呼吸反应。Sameridine 可用于镇痛作用的研究。

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Sameridine

Sameridine Chemical Structure

CAS No. : 143257-97-0

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Other Forms of Sameridine:

Sameridine 相关抗体

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查看 Opioid Receptor 亚型特异性产品:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sameridine (NIH-10908) is a weak partial agonist of the μ-opioid (μ-opioid) receptor. Sameridine shows local anesthetic and analgesic properties when injected intrathecally. Sameridine has minimal respiratory depression at low doses, but can suppress ventilatory response at high doses. Sameridine can be used for the study of analgesic effect[1][2].

IC50 & Target

μ Opioid Receptor/MOR

 

体内研究
(In Vivo)

鞘内注射 Sameridine (5-10 mg/mL (10 μL)，每天两次，每周五天，持续两周) 在大鼠模型中未引起明显的神经毒性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (weighing 320-420 g)[1].
Dosage: 5 mg/mL (10 μL), 10 mg/mL (10 μL)
Administration: Intrathecal injection, twice daily, five days a week, for two weeks.
Result: No permanent motor impairment was observed in any group.
The dorsal horn neurons in the L1 segment of the spinal cord showed normal morphology, and no signs of neurotoxicity were found, such as edema, organelle damage, necrosis, or microglia.
分子量

330.51

Formula

C21H34N2O
CAS 号
中文名称

沙美利定
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sameridine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sameridine143257-97-0NIH 10908沙美利定NIH10908NIH-10908Opioid Receptorμ-opioid partial agonistLocal anesthetic activityInhibitorinhibitorinhibit

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