2. GPCR/G Protein
  3. P2Y Receptor
  4. SAR216471

SAR216471 是一种 P2Y12 受体拮抗剂。SAR216471 可逆性地阻断 2MeSADP 与 P2Y12 受体的体外结合，IC50 值为 17 nM。SAR216471 可抑制血小板聚集。SAR216471 在大鼠模型中表现出抗血栓活性。SAR216471 可用于血栓形成的研究。

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SAR216471

SAR216471 Chemical Structure

CAS No. : 1279867-21-8

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Other Forms of SAR216471:

SAR216471 相关抗体

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查看 P2Y Receptor 亚型特异性产品:

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P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SAR216471 is a P2Y12 receptor antagonist. SAR216471 reversibly blocks the binding of 2MeSADP to P2Y12 receptors in vitro with an IC50 of 17 nM. SAR216471 can result in the inhibition of platelet aggregation. SAR216471 exhibits anti-thrombotic activity in rat model. SAR216471 can be studied in research on thrombosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
17 nM
Compound: 52w, SAR216471
Displacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysis
Displacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysis
[PMID: 25075638]
分子量

563.05

Formula

C28H31ClN8O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SAR216471 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR2164711279867-21-8SAR 216471SAR-216471P2Y ReceptorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-12435
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