2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Reactive Oxygen Species (ROS) Apoptosis CDK
  4. SB-1295

SB-1295 是一种具有口服活性的 CDK9/T1 抑制剂 (IC50=0.17 μM)。SB-1295 在 HCT 116 和 MIA PaCa-2 细胞中显示出抗增殖活性。SB-1295 还可通过诱导细胞内产生 ROS、降低线粒体膜电位并诱导细胞凋亡从而诱导 MIA PaCa-2 细胞死亡。SB-1295 具有研究癌症的潜力。

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SB-1295

SB-1295 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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SB-1295 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

生物活性

SB-1295 is an orally active CDK9/T1 inhibitor (IC50=0.17 μM). SB-1295 shows antiproliferative activity in HCT 116 and MIA PaCa-2 cells. SB-1295 also induces MIA PaCa-2 cell death by inducing intracellular ROS production, reducing mitochondrial membrane potential and inducing apoptosis. SB-1295 has the potential to study cancer[1].

IC50 & Target

IC50: 0.17 μM (CDK9/T1)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 GI50
5.1 μM
Compound: 2b; SB-1295, DD-35
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 37302342]
HEK293 GI50
90.32 μM
Compound: 2b; SB-1295, DD-35
Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 37302342]
MIA PaCa-2 GI50
6.07 μM
Compound: 2b; SB-1295, DD-35
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 37302342]
分子量

443.88

Formula

C23H22ClNO6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

SB-1295 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-1295SB1295SB 1295Reactive Oxygen Species (ROS)ApoptosisCDKCyclin dependent kinaseHCT 116MIA PaCa-2cancerROSInhibitorinhibitorinhibit

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