2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK FLT3
  4. SB1578

SB1578 (CT-1578) 是一种选择性 JAK2 和 FLT3 抑制剂，其 IC50 值分别为 46 nM 和 60 nM。SB1578 对其他激酶靶点也具有高选择性。SB1578 可用于研究非肿瘤适应症类风湿性关节炎。

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SB1578

SB1578 Chemical Structure

CAS No. : 937273-04-6

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SB1578 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB1578 (CT-1578) is a selective JAK2 and FLT3 inhibitor with an IC50 of 46 nM and 60 nM, respectively. SB1578 exhibits high selectivity for other kinase targets. SB1578 can be used for the study of non-oncology indication rheumatoid arthritis[1].

IC50 & Target[1]

JAK2

46 nM (IC50)

FLT3

60 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SET-2 IC50
0.246 nM
Compound: 14l, SB1578, 67:33 trans/Cis mixture
Antiproliferative activity against human SET2 cells expressing JAK2 V617F mutan
Antiproliferative activity against human SET2 cells expressing JAK2 V617F mutan
[PMID: 22339472]
分子量

462.54

Formula

C26H30N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB1578 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB1578937273-04-6CT-1578SB 1578SB-1578CT1578CT 1578JAKFLT3Janus kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3JAK2 and FLT3 inhibitornon-oncology indication rheumatoid arthritisInhibitorinhibitorinhibit

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目录号：
HY-16449
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