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SCP1-IN-2

目录号: HY-142683 class="icon-copy-success" style="display: none"> class="icon-copy-product-info"> 一键复制产品信息纯度: 98.77%: Data Sheet SDS COA 产品使用指南
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SCP1-IN-2 (Compound SH T-65) 是一种针对 SCP1 的强效选择性共价抑制剂。SCP1-IN-2 促进 REST 降解并降低转录活性。高水平的 REST 蛋白驱动一些胶质母细胞瘤细胞的肿瘤生长。SCP1-IN-2 具有研究由 REST 转录活动驱动生长的胶质母细胞瘤的潜力。

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SCP1-IN-2 Chemical Structure

CAS No. : 2764615-56-5

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规格	价格	是否有货
1 mg	￥1100	In-stock
5 mg	￥2700	In-stock
10 mg	￥4000	In-stock
50 mg		询价
100 mg		询价

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SCP1-IN-2 相关抗体

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SCP1-IN-2 相关产品

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生物活性
纯度 & 产品资料
参考文献

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生物活性

SCP1-IN-2 (Compound SH T-65) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-2 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-2 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity^[1].

细胞效力
(Cellular Effect)

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Cell Line	Type	Value	Description	References
HEK293	EC₅₀	class="poptip effect-temp-name" style="position: relative; padding: 0;"> 1.5 μM class="poptip-box" style="margin-left: -18px; top: auto" aria-controls=""> Compound: T-65	class="poptip-cont" style="padding: 0"> Downregulation of REST protein expression in HEK293 cells incubated for 3 days with media replenishment for every 24 hrs by immunoblot analysis class="poptip-box f14" aria-controls=""> Downregulation of REST protein expression in HEK293 cells incubated for 3 days with media replenishment for every 24 hrs by immunoblot analysis	[PMID: 34931516]

分子量

490.47

Formula

C₁₉H₁₇F₃N₂O₆S₂

CAS 号

2764615-56-5

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

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Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

class="ss-title solution-tit" id="solution-tit" style="font-style: normal">细胞实验： class="ss-vitro solution-vitro">

DMSO 中的溶解度 : 100 mg/mL (203.89 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

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浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0389 mL	10.1943 mL	20.3886 mL
5 mM	0.4078 mL	2.0389 mL	4.0777 mL
10 mM	0.2039 mL	1.0194 mL	2.0389 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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摩尔计算器
稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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浓度 _(start) class="after-line">

体积 _(start) class="after-line">

浓度 _(final) class="after-line">

体积 _(final) class="after-line">

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请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

class="invivo-step invivo-step-new">
class="ss-vivo-order step-tit">方案一
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请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.10 mM); 澄清溶液

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此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

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动物溶解方案

id="solCalcWrapper"> class="a-solution-item">动物溶解方案计算器 class="a-scheme"> class="a-scheme-tit">请输入动物实验的基本信息： class="calculator-form c-flex-form"> style="display: flex"> class="c-form-item">

给药剂量

mg/kg class="c-form-item">

动物的平均体重

g class="c-form-item">

每只动物的给药体积

μL class="c-form-item">

动物数量

只 class="c-tip">由于实验过程有损耗，建议您多配一只动物的量 class="a-scheme a-matching"> class="a-matching-tit">请输入您的动物体内配方组成： class="calculator-form c-flex-form" style="align-items: center; padding-bottom: 7px;justify-content: flex-start; flex-flow: row nowrap;"> style="position:relative;"> % DMSO + style="position: relative;"> % class="c-form-item" style="display: flex; align-items: center;" data-bind="if: opCount() > 2"> + style="position: relative; margin-right: 5px;"> % Tween-80 + style="position: relative;"> % Saline 如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。 style="margin: 10px 0;"> 方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。 class="a-scheme a-matching" style="padding-top: 0;"> > data-bind="text: lastError" class="error"> class="btn-list"> class="calculator-form" data-bind="if: isWorkConcVisible" style="padding: 5px 12px 0; margin-bottom: 0; box-sizing: border-box; overflow: visible;"> class="result-tit">计算结果 class="line"> class="result" style="margin-top: 15px;display: flex; flex-wrap: wrap;"> 工作液所需浓度 : mg/mL class="calculator-form" data-bind="if: isStepVisible" style="padding: 0 12px; margin-bottom: 0; margin-top: 0; box-sizing: border-box; overflow: visible;"> class="result" style="display: flex; flex-wrap: wrap; margin-top: 10px;"> 储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。 class="result-tip" style="position: relative;" data-bind="if: storeConc() > 100.0"> 您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。 class="tooltip-panel normal-saline-div-6" style="left: 535.453px; top: 23px; position: absolute; display: none; line-height: 24px; margin-left: -40px; padding-top: 5px; margin-top: -5px;"> class="tooltip-arrowup"> class="tooltip-container"> 免费服务热线：400-820-3792
E-mail：sales@hg.y866.cn/biomolecule
技术支持电话：021-58950656
技术支持邮箱：tech@hg.y866.cn/biomolecule class="result" style="margin-top: 10px; position:relative; display: flex; flex-wrap: wrap;"> 动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。 class="tooltip-panel normal-saline-div-5" style="left: 315.453px; top: 49.6562px; position: absolute; display: none; line-height: 24px;"> class="tooltip-arrowup"> class="tooltip-container"> 将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液 data-bind="if: isWorkCornOil">连续给药周期超过半月以上，请谨慎选择该方案。 class="result-tip lh24"> 请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

> class="details_batch">

纯度: 98.77%

选择批次： class="details_info_doc"> Data Sheet (613 KB) SDS (251 KB)

COA (285 KB) HNMR (271 KB) LCMS (88 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519. [Content Brief]

class="details_info hide" id="pro_info_4"> class="details_info hide" id="pro_info_5">

[1]. Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519.

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SCP1-IN-2 相关分类

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完整储备液配制表

class="ss-table"> id="stock-solution-tips" class="ss-table-tip">

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0389 mL	10.1943 mL	20.3886 mL	50.9715 mL
	5 mM	0.4078 mL	2.0389 mL	4.0777 mL	10.1943 mL
	10 mM	0.2039 mL	1.0194 mL	2.0389 mL	5.0972 mL
	15 mM	0.1359 mL	0.6796 mL	1.3592 mL	3.3981 mL
	20 mM	0.1019 mL	0.5097 mL	1.0194 mL	2.5486 mL
	25 mM	0.0816 mL	0.4078 mL	0.8155 mL	2.0389 mL
	30 mM	0.0680 mL	0.3398 mL	0.6796 mL	1.6991 mL
	40 mM	0.0510 mL	0.2549 mL	0.5097 mL	1.2743 mL
	50 mM	0.0408 mL	0.2039 mL	0.4078 mL	1.0194 mL
	60 mM	0.0340 mL	0.1699 mL	0.3398 mL	0.8495 mL
	80 mM	0.0255 mL	0.1274 mL	0.2549 mL	0.6371 mL
	100 mM	0.0204 mL	0.1019 mL	0.2039 mL	0.5097 mL

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data-bind="click: $root.toggleFaq"> Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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