2. Anti-infection
  3. SARS-CoV Hepatitis E Virus (HEV) Filovirus
  4. SCR007

SCR007 是一种具有广谱抗病毒活性的合成碳水化合物受体 (SCR)。SCR007 抑制多种病毒家族的包膜病毒进入 (冠状病毒科：SARS-CoV-1、SARS-CoV-2、MERS-CoV；丝状病毒科：EBOV、MARV；副黏病毒科：NiV、HeV) 以及糖基化的非包膜轮状病毒。SCR007 结合病毒包膜 N-糖基，阻断病毒与宿主细胞的结合或同时阻断结合和膜融合。SCR007 在感染 SARS-CoV-2 的 hACE2 小鼠中发挥预防作用。SCR007 可用于包膜病毒大流行的研究和预防。

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SCR007

SCR007 Chemical Structure

CAS No. : 2409183-72-6

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Customer Review

SCR007 相关抗体

Top Publications Citing Use of Products

查看 Filovirus 亚型特异性产品:

查看所有亚型
EBOV MARV ZEBOV

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SCR007 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR007 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR007 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR007 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR007 can be used for the study and prevention of enveloped virus pandemics[1].

体外研究
(In Vitro)

SCR007 (10-40 μM) 在 PRNT 和 IFA 实验中抑制 SARS-CoV-2 (WA.1 株)、MERS-CoV、EBOV、MARV、NiV 和 HeV 的感染，具有强效的抑制效能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SCR007 相关抗体:
体内研究
(In Vivo)

SCR007 (3 mg/kg，鼻内给药，单剂量) 提高感染 SARS-CoV-2 的 hACE2 小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hACE2 knock-in mice (4-5-month-old) were intranasally challenged with 2 × 103 PFU of SARS-CoV-1/2[1]
Dosage: 3 mg/kg
Administration: i.n., single dose
Result: Achieved 90% survival rate.
Reduced lung viral RNA copies by multiple orders of magnitude and brain viral RNA copies significantly.
Decreased perivascular infiltrates and necrotic neurons in lung and brain tissues.
Reduced lung live virus titer.
Decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), with TNFα, IL-18 and IFN-γ reduced.
分子量

646.91

Formula

C36H30N4S4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SCR007 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCR0072409183-72-6SCR 007SCR-007SARS-CoVHepatitis E Virus (HEV)FilovirusSARS coronavirusHepatitis E VirushACE2 miceSARS-CoV-2SARS-CoV-1MERS-CoVEBOVMARVNiVHeVInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-178137
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