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  3. 高效基因编辑化合物库
高效基因编辑化合物库 - High-Efficiency Gene Editing Compound Library

Cat. No.: HY-L244

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在基因编辑技术飞速发展的时代,CRISPR-Cas 系统以其强大的可编程性引领了生命科学研究的变革。CRISPR-Cas 高效且精确地对生物体的基因组进行目标修饰,为研究基因功能、治疗遗传性疾病以及改良作物品种提供了强大的工具。然而,编辑效率不足、同源定向修复效率低下及潜在脱靶风险等瓶颈,仍是实现精准基因修饰与开发基因疗法的主要挑战。

为突破这些限制,MCE 高效基因编辑化合库系统收录了 698 个可明确或潜在提升基因编辑效率的小分子。这些化合物通过靶向调控 DNA 损伤修复网络,从机制上抑制非同源末端连接、促进同源定向修复或调节染色质状态与细胞应答,从而显著优化编辑效果。该库适用于开发“CRISPR-小分子”联合治疗策略,提升基因编辑效率,并为深入研究 DNA 损伤修复在基因编辑中的相关机制提供有力工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 高效基因编辑化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,674 个产品以 10 mM 浓度提供,23 个产品以 2 mM 浓度提供,1 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情

活性描述 & 特点

Biological Activity

•    A collection of compounds with clear or potential capabilities to enhance the efficiency of gene editing, suitable for high-throughput screening (HTS) and high-content screening (HCS).

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 698 compounds with definite or potential gene-editing-enhancing activity supplied as pre-dissolved Solutions or Solid.
Solution: 674 compounds supplied in 10 mM solution, 23 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    High-Efficiency Gene Editing Compound Library
    目录号:
    HY-L244
    需求量: