1. 一站式药筛
  2. 化合物库
  3. 模式识别受体库
模式识别受体库 - Pattern Recognition Receptors Library

Cat. No.: HY-L237

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模式识别受体 (Pattern Recognition Receptors, PRRs) 是先天免疫系统细胞 (如巨噬细胞、树突状细胞等) 中表达的一类重要蛋白质分子。模式识别受体的核心作用是识别病原体相关分子模式 (Pathogen-Associated Molecular Patterns, PAMPs) 和损伤相关分子模式 (Damage-Associated Molecular Patterns, DAMPs)。当PRRs识别并结合 PAMPs 或 DAMPs 后,会迅速启动细胞内信号通路 (如 NF-κB、IRF、炎症小体通路),从而触发炎症因子、趋化因子和 I 型干扰素等的产生,启动炎症反应,清除病原体或修复损伤。PRRs 是机体抵抗感染的第一道防线,其应答的快速性和广泛性对宿主存活至关重要。然而,PRR 信号的异常活化也是许多慢性炎症性疾病、自身免疫病和神经退行性疾病的原因之一。因此,精准调控 PRR 的活性已成为治疗这些疾病的关键策略。

MCE 精心收录了 278 种具有明确或潜在免疫增强作用的化合物,主要靶向 NOD-like Receptor (NLR)、Toll-like Receptor (TLR)、C-type Lectin-like Receptors、Cyclic GMP-AMP Synthase 等,是慢性炎症疾病等相关药物研究的有效工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 模式识别受体库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,271 个产品以 10 mM 浓度提供,3 个产品以 2 mM 浓度提供,4 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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活性描述 & 特点

Biological Activity

•    A unique collection of 278 inhibitors of pattern recognition receptors for high throughput screening (HTS) and high content screening (HCS).

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 278 inhibitors of pattern recognition receptors supplied as pre-dissolved Solutions or Solid.
Solution: 271 compounds supplied in 10 mM solution, 3 compounds supplied in 2 mM solution, 4 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Pattern Recognition Receptors Library
    目录号:
    HY-L237
    需求量: