2. GPCR/G Protein Protein Tyrosine Kinase/RTK Neuronal Signaling Apoptosis MAPK/ERK Pathway Autophagy
  3. GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family
  4. Semaglutide sodium

Semaglutide sodium 是一种长效、选择性、竞争型 GLP-1R 激动剂，能透过血脑屏障。Semaglutide sodium 激活 GLP-1R 后促进胰岛素分泌、抑制胃排空和食欲，同时通过增强自噬 (autophagy)、抑制氧化应激和凋亡 (apoptosis)。Semaglutide 还调节线粒体功能及脂质代谢 ( 如减少肝内从头脂肪生成 ) 。Semaglutide sodium 具有降血糖、减重、神经保护 ( 如改善帕金森病模型中的运动功能、减少 α- 突触核蛋白 (α-synuclein) 聚集 ) 及改善肝脂肪变性等活性。Semaglutide sodium 可用于 2 型糖尿病、肥胖症、帕金森病、代谢相关脂肪性肝病 (MASLD) 等神经退行性疾病和肝脏疾病，以及癌症的研究。

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CAS No. : 2924330-56-1

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Semaglutide sodium 的其他形式现货产品:

Customer Review

Other Forms of Semaglutide sodium:

Semaglutide sodium 相关抗体

Top Publications Citing Use of Products

    Semaglutide sodium purchased from MCE. Usage Cited in: Int J Mol Med. 2021 Dec;48(6):219.  [Abstract]

    Proliferation of BV2 cells treated with semaglutide at different concentrations (300, 600, 900 and 1,000 nM) was assessed using Cell Counting Kit‑8 analysis.

    Semaglutide sodium purchased from MCE. Usage Cited in: Int J Mol Med. 2021 Dec;48(6):219.  [Abstract]

    Representative WB images in different BV2 cell groups with semaglutide (900 nM,20 h).

    Semaglutide sodium purchased from MCE. Usage Cited in: Int J Mol Med. 2021 Dec;48(6):219.  [Abstract]

    Semaglutide (10 and 25 nM/kg; ip.; single dose) decreased the fluorescence intensity of caspase‑3, Bax and Bcl-2 in the CA1 and CA3 regions.

    Semaglutide sodium purchased from MCE. Usage Cited in: Int J Mol Med. 2021 Dec;48(6):219.  [Abstract]

    Western blot showing that 10 and 25 nM/kg semaglutide, i.p, reduced the band intensity of active caspase‑3 and increased the Bcl‑2/Bax ratio.

    Semaglutide sodium purchased from MCE. Usage Cited in: Int J Mol Med. 2021 Dec;48(6):219.  [Abstract]

    Semaglutide (10-25 nM/kg; i.p.; single dose) reduced the mRNA levels of NLRP3, ASC and caspase-1 p20.

    查看 α-synuclein 亚型特异性产品:

    查看所有亚型
    α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

    查看 p38 MAPK 亚型特异性产品:

    查看所有亚型
    p38 MAPK p38α p38β MAPK13 p38δ p38γ

    查看 Bcl-2 Family 亚型特异性产品:

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    Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Semaglutide sodium is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide sodium promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide sodium also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide sodium has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide sodium can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer[1][2][3][4][5].

    体外研究
    (In Vitro)

    1. 抗 Aβ25-35 损伤实验：
    Semaglutide (1-100 nM；24 h) sodium 显著提高 SH-SY5Y 细胞的存活率，增加 LC3II、Atg7、Beclin-1 和 P62 等自噬相关蛋白表达，抑制 Bax 并上调 Bcl-2，通过增强自噬、抑制凋亡并保护神经细胞[1][2]。
    2. 口腔鳞状细胞癌 (OSCC) 细胞实验：
    Semaglutide (5-40 μM；48 h) sodium 剂量依赖性抑制 Cal27 和 HSC4 细胞的增殖、迁移及侵袭，上调 E-cadherin 并下调 Vimentin，激活 P38 MAPK 信号通路 (p-P38 表达增加)，诱导细胞凋亡[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Semaglutide sodium 相关抗体:

    Cell Viability Assay[1][2]

    Cell Line: SH-SY5Y human neuroblastoma cells
    Concentration: 0, 1, 10, 100 nM
    Incubation Time: 24 h
    Result: Cell Viability: Significantly increased cell survival rate in a dose-dependent manner, reversing Aβ25-35-induced cytotoxicity.
    WB (Western Blot): Upregulated autophagy markers (LC3II, Atg7, Beclin-1, P62) and anti-apoptotic protein Bcl-2, while downregulating pro-apoptotic protein Bax.
    体内研究
    (In Vivo)

    此产品非口服制剂，进行动物实验时，可选择皮下或者腹腔注射。
    口腔鳞状细胞癌 (OSCC) 移植瘤模型
    Semaglutide (3 μmol/kg；皮下注射；每周 3 次；3 周) sodium 显著抑制裸鼠口腔鳞状细胞癌 (OSCC) 移植瘤模型的肿瘤体积增长，下调增殖标志物 Ki67 和 PCNA，上调促凋亡蛋白 Bax 并下调抗凋亡蛋白 Bcl-xL，通过激活 P38 MAPK 通路诱导肿瘤细胞凋亡[3]。
    慢性 MPTP 诱导的帕金森病模型
    Semaglutide (25 nmol/kg；腹腔注射；每 2 天 1 次；30 天) sodium 改善小鼠慢性 MPTP 诱导的帕金森病模型及其运动功能障碍，增加黑质酪氨酸 (TH) 阳性神经元数量，减少 α- 突触核蛋白聚集及胶质细胞活化，降低氧化应激标志物 4-HNE 水平[4]。
    代谢功能障碍相关脂肪性肝病 (MASLD) 模型
    Semaglutide (25 μg/kg/ 周 + 100 μg/kg/ 周；皮下注射；每周 1 次；11 周) sodium 在小鼠代谢功能障碍相关脂肪性肝病 (MASLD) 模型中，降低小鼠体重、血糖及血清肝酶 (ALT、AST、AP)，减少肝内甘油三酯沉积，改善肝脂肪变性及肝细胞气球样变，下调从头脂肪生成标志物 Acaca 和 Scd1[5]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    4113.58 (free base)

    Formula

    C187H291N45O59·xNa
    CAS 号
    Sequence

    His-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-{C18 diacid-γ-Glu-(AEEA)2-Lys}-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
    Sequence Shortening

    H-{Aib}-EGTFTSDVSSYLEGQAA-{C18 diacid-γ-Glu-(AEEA)2-Lys}-​​​EFIAWLVRGRG
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Semaglutide sodium 相关分类

    • 摩尔计算器

    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Semaglutide2924330-56-1GLP ReceptorInsulin Receptorα-synucleinApoptosisp38 MAPKAutophagyBcl-2 Familyα-SynInhibitorinhibitorinhibit

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