2. Epigenetics
  3. Histone Methyltransferase
  4. SET7-IN-DC21

SET7-IN-DC21 是一种选择性强、效力高的 SET7 抑制剂 (IC50 = 15.93 μM；KD = 18.00 μM)。DC21 其他几种表观遗传靶点具有良好的选择性，例如 SUV39H1、G9a、NSD1、DOT1L 和 MOF。DC21 可用于癌症、感染、炎症、代谢性疾病和心血管疾病的研究，如乳腺癌。

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SET7-IN-DC21

SET7-IN-DC21 Chemical Structure

CAS No. : 2567886-53-5

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SET7-IN-DC21 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SET7-IN-DC21 is a selective, potent SET7 inhibitor (IC50 = 15.93 μM; KD = 18.00 μM). SET7-IN-DC21 has good selectivity for several other epigenetic targets, such as SUV39H1, G9a, NSD1, DOT1L and MOF. SET7-IN-DC21 can be used for the researches of cancer, infection, inflammation, metabolic and cardiovascular disease, such as breast cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
25.84 μM
Compound: DC21
Antiproliferative activity against human MCF7 cells expresses endogenous ER by Cell Titer-Glo based luminescence assay
Antiproliferative activity against human MCF7 cells expresses endogenous ER by Cell Titer-Glo based luminescence assay
[PMID: 32173197]
体外研究
(In Vitro)

SET7-IN-DC21 (0.5-2.5 μM，72 h) 以剂量依赖的方式抑制 MCF7 细胞的增殖 (IC50 = 25.84 μM)，对正常细胞 (包括正常胚肺成纤维细胞系 MRC-5 和脐静脉内皮细胞系 HUV-EC-C) 的增殖几乎没有影响[1]。
SET7-IN-DC21 (6.25-200 μM，72 h) 可以降低 ERα 的稳定性，从而以剂量依赖的方式降低 MCF7 细胞系中 ERα 蛋白的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SET7-IN-DC21 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF7 cells, HUV-EC-C cells, MRC-5 cells
Concentration: 0.5 μM, 1 μM, 1.5 μM, 2 μM, 2.5 μM
Incubation Time: 72 h
Result: Inhibited the proliferation of MCF7 cells in a dose-dependent manner (IC50 = 25.84 μM), and had little effect on the proliferation of normal cells, including normal embryonic lung fibroblast cell line MRC-5 and umbilical vascular endothelial cell line HUV-EC-C.

Cell Viability Assay[1]

Cell Line: MCF7 cells
Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM, 200 μM
Incubation Time: 72 h
Result: Dose-dependently reduced the protein expression level of estrogen receptor α (ERα) in MCF7 cells.
分子量

232.19

Formula

C12H8O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SET7-IN-DC21 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SET7-IN-DC212567886-53-5Histone MethyltransferaseHistone methylationMolecular probeSET7Small-molecule inhibitorVirtual screeningInhibitorinhibitorinhibit

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