2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis HCV SARS-CoV
  4. Setrobuvir

Setrobuvir (ANA598) 是一种口服活性的非核苷 HCV NS5B 聚合酶抑制剂。Setrobuvir 抑制 RNA 的从头合成 (RNA synthesis) 和引物延伸，IC50在 4~5 nM 之间。Setrobuvir 还显示出与 SARS-CoV-2 RdRp 的优异结合亲和力，并诱导 RdRp 抑制。

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Setrobuvir

Setrobuvir Chemical Structure

CAS No. : 1071517-39-9

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规格 价格 是否有货 数量
1 mg ￥2805
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Setrobuvir 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 CC50
100 μM
Compound: 38, ANA-598
Cytotoxicity against human HuH7 cells
Cytotoxicity against human HuH7 cells
[PMID: 22516671]
Huh-7 CC50
> 100 μM
Compound: 2c
Cytotoxicity against human HuH7 cells assessed as GAPDH release
Cytotoxicity against human HuH7 cells assessed as GAPDH release
[PMID: 19818610]
Huh-7 EC50
3 nM
Compound: 38, ANA-598
Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication by replicon assay
Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication by replicon assay
[PMID: 22516671]
Huh-7 EC50
52 nM
Compound: 38, ANA-598
Antiviral activity against Hepatitis C virus genotype 1a infected in human HuH7 cells assessed as inhibition of viral replication by replicon assay
Antiviral activity against Hepatitis C virus genotype 1a infected in human HuH7 cells assessed as inhibition of viral replication by replicon assay
[PMID: 22516671]
体外研究
(In Vitro)

Setrobuvir (ANA598) is a non-nucleoside inhibitor that binds to the palm pocket of the HCV polymerase and has an EC50 against HCV genotype 1b/Con1-containing subgenomic replicons in the nanomolar range. Setrobuvir appears to inhibit both de novoinitiated RNA synthesis and primer extension, and its activity is unchanged by the presence of mutations that modify the activity of thumb-binding non-nucleoside inhibitors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Setrobuvir 相关抗体:
Clinical Trial
分子量

560.62

Formula

C25H25FN4O6S2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 252.5 mg/mL (450.39 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7837 mL 8.9187 mL 17.8374 mL
5 mM 0.3567 mL 1.7837 mL 3.5675 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Setrobuvir 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7837 mL 8.9187 mL 17.8374 mL 44.5935 mL
5 mM 0.3567 mL 1.7837 mL 3.5675 mL 8.9187 mL
10 mM 0.1784 mL 0.8919 mL 1.7837 mL 4.4593 mL
15 mM 0.1189 mL 0.5946 mL 1.1892 mL 2.9729 mL
20 mM 0.0892 mL 0.4459 mL 0.8919 mL 2.2297 mL
25 mM 0.0713 mL 0.3567 mL 0.7135 mL 1.7837 mL
30 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
40 mM 0.0446 mL 0.2230 mL 0.4459 mL 1.1148 mL
50 mM 0.0357 mL 0.1784 mL 0.3567 mL 0.8919 mL
60 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
80 mM 0.0223 mL 0.1115 mL 0.2230 mL 0.5574 mL
100 mM 0.0178 mL 0.0892 mL 0.1784 mL 0.4459 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Setrobuvir1071517-39-9ANA598ANA 598ANA-598DNA/RNA SynthesisHCVSARS-CoVHepatitis C virusSARS coronaviruspolymeraseRNAsynthesisprimerextensionmutationInhibitorinhibitorinhibit

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