2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Cell Cycle/DNA Damage
  3. Bacterial Reactive Oxygen Species (ROS) Interleukin Related DNA/RNA Synthesis
  4. SGNLTKYWKKIWKPGIKKWIK

SGNLTKYWKKIWKPGIKKWIK 是一种靶向胸苷酸激酶 (TMK) 抗菌肽，KD 值为 4.721 μM。SGNLTKYWKKIWKPGIKKWIK 通过膜破坏、诱导 ROS、结合 DNA 等多重机制发挥抗菌作用。SGNLTKYWKKIWKPGIKKWIK 对抗革兰氏阴性菌效果显著、生物相容性好且不易诱导耐药。SGNLTKYWKKIWKPGIKKWIK 可用于革兰氏阴性菌感染方面的研究<。

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Custom Peptide Synthesis

SGNLTKYWKKIWKPGIKKWIK

SGNLTKYWKKIWKPGIKKWIK Chemical Structure

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SGNLTKYWKKIWKPGIKKWIK 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SGNLTKYWKKIWKPGIKKWIK is a thymidylate kinase (TMK)-targeting antimicrobial peptide with a KD value of 4.721 μM. SGNLTKYWKKIWKPGIKKWIK exerts antimicrobial effects through multiple mechanisms, including membrane disruption, induction of ROS, and DNA binding. SGNLTKYWKKIWKPGIKKWIK shows remarkable activity against Gram-negative bacteria, possesses good biocompatibility, and rarely induces drug resistance. SGNLTKYWKKIWKPGIKKWIK can be used for research on Gram-negative bacterial infections[1].

IC50 & Target[1]

IL-6

 

IL-1β

 

体外研究
(In Vitro)

SGNLTKYWKKIWKPGIKKWIK (2-128 μM；12-18 h) 可强效抑制大肠杆菌 K88 生长，其 MIC 为 2 μM[1]。
SGNLTKYWKKIWKPGIKKWIK (2 μM; 1 h) 可破坏大肠杆菌 K88 的膜完整性，提高外膜/内膜通透性，使膜去极化[1]。
SGNLTKYWKKIWKPGIKKWIK (1-64 μM; 2 h) 可诱导大肠杆菌 K88 产生活性氧[1]。
SGNLTKYWKKIWKPGIKKWIK (0-256 μM; 40 min) 可结合大肠杆菌 K88 基因组 DNA，抑制 DNA 迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SGNLTKYWKKIWKPGIKKWIK 相关抗体:
体内研究
(In Vivo)

SGNLTKYWKKIWKPGIKKWIK (20 mg/kg; i.p.; single dose) 可有效清除小鼠腹膜炎模型重要器官中的致病菌，抑制炎症因子的产生并减轻器官损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (female, 6 weeks old, 20.00 ± 2 g, challenged with Escherichia coli K88 suspension)[1]
Dosage: 20 mg/kg
Administration: i.p.; single dose
Result: Significantly reduced bacterial loads in liver, kidney, spleen, and lung.
Alleviated tissue damage (vacuolar degeneration of hepatocytes, renal tubular epithelial cell edema, granulocyte infiltration in spleen and lungs).
Reduced serum levels of proinflammatory cytokines (IL-6, IL-1β, TNF-α) and HMGB1.
分子量

2603.16

Formula

C128H200N32O26
Sequence

Ser-Gly-Asn-Leu-Thr-Lys-Tyr-Trp-Lys-Lys-Ile-Trp-Lys-Pro-Gly-Ile-Lys-Lys-Trp-Ile-Lys
Sequence Shortening

SGNLTKYWKKIWKPGIKKWIK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SGNLTKYWKKIWKPGIKKWIK 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGNLTKYWKKIWKPGIKKWIKBacterialReactive Oxygen Species (ROS)Interleukin RelatedDNA/RNA SynthesisILROSEscherichia coli (K88)Gram-negative bacteriaRAW 264.7mouse peritonitis modelInhibitorinhibitorinhibit

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