2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. SHR-1906

SHR-1906 是一款靶向 CTGF 选择性全人源化单克隆 IgG1 抑制性抗体。SHR-1906 可特异性结合结缔组织生长因子 (CTGF)，阻断 CTGF 与转化生长因子 β1 (TGF-β1)的结合，阻断率达 55%。SHR-1906 在 Bleomycin (HY-108345) 诱导的小鼠中通过降低 TGF-β1 水平、抑制肺组织纤维化病变，显著提高存活率。SHR-1906 可用于肺纤维化 (特发性肺纤维化，IPF) 相关研究。推荐的同型对照为 Human IgG1 kappa，同型对照 (HY-P99001)sup>[1]。

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SHR-1906

SHR-1906 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

SHR-1906 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SHR-1906 is a selective fully humanized monoclonal IgG1 inhibitory antibody targeting CTGF. SHR-1906 specifically binds to CTGF, thereby blocking the interaction between CTGF and TGF-B1 with an inhibition rate of 55%. SHR-1906increases the survival rate in a pulmonary fibrosis model by reducing TGF-β1 levels and inhibiting fibrotic lesions in lung tissue in Bleomycin (HY-108345)-induced pulmonary fibrosis.SHR-1906 can be used for pulmonary fibrosis (IPF) research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1].

反应种属

Human
IC50 & Target[1]

CTGF

 

体内研究
(In Vivo)

SHR-1906 可剂量依赖性降低肺泡灌洗液中转化生长因子 β1 (TGF-β1) 的含量，抑制肺组织结构的破坏与纤维灶的形成，减少肺组织中的胶原沉积，并提高 Bleomycin (HY-108345) 诱导的小鼠肺纤维化模型的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

1490  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SHR-1906 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHR-1906SHR1906SHR 1906TGF-beta/SmadTransforming growth factor betafully humanized monoclonal IgG1 antibodyconnective tissue growth factorpulmonary fibrosisInhibitorinhibitorinhibit

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目录号：
HY-P991950
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