2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs Anaplastic lymphoma kinase (ALK)
  4. SIAIS001

SIAIS001 是一种强效且口服有效的 PROTAC ALK 降解剂，其 DC50 为 3.9 nM。SIAIS001 可诱导 G1/S 期细胞周期阻滞并抑制 SR 细胞增殖 (IC50 = 0.9 nM)。SIAIS001 可用于非小细胞肺癌 (NSCLC) 和间变性大细胞淋巴瘤 (ALCL) 的研究。
(粉色: Anaplastic lymphoma kinase (ALK) 配体 (HY-13011)；蓝色: TNF Receptor 配体 (HY-138793)；黑色: 连接子)。

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SIAIS001

SIAIS001 Chemical Structure

CAS No. : 2570251-63-5

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SIAIS001 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIAIS001 is a potent and orally active PROTAC ALK degrader with a DC50 of 3.9 nM. SIAIS001 induces G1/S phase cell cycle arrest and inhibits proliferation of SR cells (IC50 = 0.9 nM). SIAIS001 can be used for non-small cell lung cancer (NSCLC) and anaplastic large-cell lymphomas (ALCLs) research[1]. (Pink: Anaplastic lymphoma kinase (ALK) ligand (HY-13011); Blue: TNF Receptor ligand (HY-138793); Black: linker).

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SR IC50
0.9 nM
Compound: C26; SIAIS001
Antiproliferative activity against ALK positive human SR cells
Antiproliferative activity against ALK positive human SR cells
[PMID: 33751979]
分子量

789.96

Formula

C48H51N7O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SIAIS001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIAIS0012570251-63-5SIAIS 001SIAIS-001PROTACsAnaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246PROTACSR cellsNSCLCALCLsInhibitorinhibitorinhibit

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目录号：
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