2. Immunology/Inflammation Cytoskeleton Cell Cycle/DNA Damage
  3. Salt-inducible Kinase (SIK) PAK
  4. SIK2/3-IN-2

SIK2/3-IN-2 (compound 12, compound I-200) 是一种强效的 SIK2/3 抑制剂（SIK2 IC50 = 65 nM，SIK3 IC50 = 14 nM）。SIK2/3-IN-2 也是一种 p21 活化蛋白激酶 (PAK)1 抑制剂，其 Ki 值为 20.7 nM。SIK2/3-IN-2 可用于增殖性疾病和癌症研究，例如紫杉醇 (HY-B0015) 耐药性卵巢癌。

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SIK2/3-IN-2

SIK2/3-IN-2 Chemical Structure

CAS No. : 1648864-21-4

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SIK2/3-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Salt-inducible Kinase (SIK) 亚型特异性产品:

查看所有亚型
SIK1 SIK2 SIK3

查看 PAK 亚型特异性产品:

查看所有亚型
PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor (SIK2 IC50 = 65 nM, SIK3 IC50 = 14 nM). SIK2/3-IN-2 is also a p21-activated protein kinase (PAK) 1 inhibitor with a Ki of 20.7 nM. SIK2/3-IN-2 can be used for hyperproliferative diseases and cancer research, such as Paclitaxel (HY-B0015)-resistant ovarian cancer[1][2].

IC50 & Target[1][2]

PAK1

20.7 nM (Ki)

SIK2

65 nM (IC50)

SIK3

14 nM (IC50)

分子量

492.96

Formula

C25H25ClN6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SIK2/3-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIK2/3-IN-21648864-21-4Salt-inducible Kinase (SIK)PAKp21 activated kinasesp21-activated protein kinasehyperproliferative diseasesPaclitaxel-resistant ovarian cancerInhibitorinhibitorinhibit

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