2. PI3K/Akt/mTOR Epigenetics Cell Cycle/DNA Damage
  3. PI3K HDAC Akt Histone Methyltransferase
  4. SJY26

SJY26 是一种 PI3K/HDAC 双靶点抑制剂，其 IC50 值分别为 0.59 nM (PI3Kα 和 PI3Kδ)、2.02 nM (PI3Kγ)、12.69 nM (PI3Kβ) 和 114 nM (HDAC1)。SJY26 具有强效的广谱抗增殖活性，尤其对 Jurkat 和 PC9R 细胞极为敏感。SJY26 可抑制 PC9R 细胞的迁移，阻滞细胞周期并诱导细胞凋亡 (apoptosis)。SJY26 可降低 AKT 磷酸化水平，并减少组蛋白 H3 (Ac-H3) 的去乙酰化。SJY26 可用于非小细胞肺癌和白血病的研究。

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SJY26

SJY26 Chemical Structure

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Customer Review

SJY26 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SJY26 is a PI3K/HDAC dual-target inhibitor with IC50s of 0.59 nM (PI3Kα and PI3Kδ), 2.02 nM (PI3Kγ), 12.69 nM (PI3Kβ) and 114 nM (HDAC1). SJY26 exhibits potent broad-spectrum anti-proliferative activity, and is particularly sensitive to Jurkat and PC9R cells. SJY26 inhibited the migration of PC9R cells, arrested the cell cycle and induced cell apoptosis. SJY26 reduces AKT phosphorylation, and decreases histone H3 deacetylation (Ac-H3). SJY26 can be used for the studies of non-small cell lung cancer and leukemia[1].

IC50 & Target[1]

PI3Kα

0.59 nM (IC50)

PI3Kδ

0.59 nM (IC50)

PI3Kγ

2.02 nM (IC50)

PI3Kβ

12.69 nM (IC50)

HDAC1

114 nM (IC50)

体外研究
(In Vitro)

SJY26 (24 h) 对 Jurkat、PC9R、MCF-7 和 K562 细胞表现出强效的抑制活性，IC50 值分别为 0.38 μM、0.59 μM、1.98 μM 和 4.30 μM[1]。
SJY26 (1.25-2.5 μM，0-48 h) 以浓度依赖的方式有效抑制 PC9R 细胞的迁移能力[1]。
SJY26 (2.5 μM，24 h) 使 PC9R 细胞停滞在 G2/M 期，阻止其进入有丝分裂并完成增殖[1]。
SJY26 (2.5-5 μM，48 h) 以浓度依赖的方式诱导 PC9R 细胞凋亡[1]。
SJY26 (2.5-5 μM，24 h) 在 PC9R 细胞中可下调 PI3K-AKT 信号通路，同时上调组蛋白乙酰化水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SJY26 相关抗体:

Cell Migration Assay [1]

Cell Line: PC9R cells
Concentration: 1.25 μM and 2.5 μM
Incubation Time: 0, 24 and 48 h
Result: Effectively inhibited the migration ability of PC9R cells in a concentration-dependent manner.

Cell Cycle Analysis[1]

Cell Line: PC9R cells
Concentration: 2.5 μM
Incubation Time: 24 h
Result: Significantly increased the proportion of cells in the G2/M phase.

Apoptosis Analysis[1]

Cell Line: PC9R cells
Concentration: 2.5 μM and 5 μM
Incubation Time: 48 h
Result: Induced cell apoptosis in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: PC9R cells
Concentration: 2.5 μM and 5 μM
Incubation Time: 24 h
Result: Down-regulated the PI3K-AKT signaling pathway while up-regulated the level of histone acetylation.
分子量

680.68

Formula

C35H26F2N6O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SJY26 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJY26SJY 26SJY-26PI3KHDACAktHistone MethyltransferasePhosphoinositide 3-kinaseHistone deacetylasesPKBProtein kinase BAntitumorDual-targetInhibitorinhibitorinhibit

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