2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. SLD1121

SLD1121 是一种 Wnt/β-catenin 信号通路的激动剂，可通过靶向 LRP6 (Kd: 4.52-7.49 nM) 增强 Wnt 信号。SLD1121 可与 LRP6 的细胞内结构域相互作用，稳定 LRP6，促进其核转位，并在细胞核内促进其与 β-catenin、TCF4 或 LEF1 结合，从而诱导 Wnt 调控基因和干细胞相关基因的表达。SLD1121 可诱导小鼠毛发生长周期中毛囊由休止期向生长期转变，促进小鼠毛发生长。SLD1121 可用于脱发相关研究。

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SLD1121

SLD1121 Chemical Structure

CAS No. : 2759011-75-9

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SLD1121 相关抗体

Top Publications Citing Use of Products

查看 Wnt 亚型特异性产品:

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Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research[1].

体外研究
(In Vitro)

SLD1121 (0-2 μM; 24 h) 可在 HEK293T 细胞中激活 LRP6 介导的 Wnt/β-catenin 信号通路，其 EC50 约为 0.21 μM[1]。
SLD1121 (1-2 μM; 24 h) 可激活 HaCaT 细胞中的 Wnt/β-catenin 信号通路[1]。
SLD1121 (0.25-2 μM; 4-24 h) 可在 HEK293T 和 HaCaT 细胞中以剂量和时间依赖的方式提升总 LRP6 蛋白水平、磷酸化 LRP6 蛋白水平，以及 ABC 和 β-catenin 的水平，且不会改变 LRP6 的 mRNA 表达水平[1]。
SLD1121 (2 μM; 24 h) 可在 HEK293T 细胞中直接与 LRP6 相互作用，会提高内源性及外源性 LRP6 的热稳定性[1]。
SLD1121 (0-2 μM; 12-24 h) 可促进 HaCaT 细胞中 LRP6 的核转位并提升核内 β-catenin 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SLD1121 相关抗体:

Real Time qPCR[1]

Cell Line: HaCaT cells
Concentration: 1 and 2 μM
Incubation Time: 24 h
Result: Upregulated the mRNA expression of Wnt target genes Axin2, LEF1, Snail1, OCT4, Twist1, Sox2, and CD44.
体内研究
(In Vivo)

SLD1121 (2%; topical; daily; 17 days) 可激活脱毛 C57BL/6J 小鼠体内的 Wnt/β-catenin 信号通路，诱导毛囊从休止期向生长期转变，并显著促进毛发再生及再生毛发的重量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (7-week-old female, depilated to induce synchronized hair follicle telogen phase)[1]
Dosage: 2%
Administration: topical; daily; 17 days
Result: Induced gray skin (indicating early anagen transition) on day 9.
Showed significantly higher hair coat recovery rates compared to vehicle controls on days 11, 15, and 17.
Increased regrown hair weight significantly relative to vehicle controls on day 17.
Increased anagen-phase hair follicle numbers and dermal thickness compared to vehicle-treated mice (remained in telogen) via histological H&E staining.
Upregulated protein levels of phosphorylated LRP6, total LRP6, ABC, β-catenin, cytokeratin 15, and cytokeratin 17 significantly via western blotting.
Increased expression of LRP6, β-catenin, ABC, cytokeratin 15, cytokeratin 17, and proliferative marker Ki67 in skin tissues confirmed via immunohistochemical staining.
Increased expression of Sox2 and Snail in hair follicles shown via immunofluorescence staining.
分子量

415.45

Formula

C26H17N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SLD1121 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLD11212759011-75-9SLD 1121SLD-1121Wntβ-cateninBeta cateninLEF1HaCaT cellsWnt/β-catenin signalinghair folliclesLRP6HEK293T cellsC57BL/6J micealopeciaInhibitorinhibitorinhibit

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