2. Apoptosis
  3. IAP Apoptosis
  4. SM-122

SM-122 是一种单价 Smac 模拟物，靶向细胞凋亡抑制蛋白 (cIAP)-1/2。SM-122 可诱导 cIAP-1/2 降解，并微弱诱导肿瘤细胞中的凋亡 (apoptosis)。SM-122 可用于癌症研究，如乳腺癌。

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SM-122

SM-122 Chemical Structure

CAS No. : 874270-38-9

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SM-122 相关抗体

Top Publications Citing Use of Products

查看 IAP 亚型特异性产品:

查看所有亚型
cIAP cIAP-1 cIAP-2 XIAP

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein (cIAP)-1/2. SM-122 can induce cIAP-1/2 degradation and weakly induce apoptosis in tumor cells. SM-122 can be used for the research of cancer, such as breast cancer[1].

IC50 & Target[1]

cIAP-1

 

cIAP-2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
1400 nM
Compound: 18; SM-122
Cytotoxicity against human HL60 cells assessed as reduction in cell viability
Cytotoxicity against human HL60 cells assessed as reduction in cell viability
[PMID: 30676015]
MDA-MB-231 EC50
1.03 μM
Compound: 1, SM-122
Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay
Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay
[PMID: 19049347]
MDA-MB-231 IC50
259 nM
Compound: 1, SM-122
Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay
Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay
[PMID: 19049347]
MDA-MB-231 IC50
259 nM
Compound: 7, SM-122
Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay
Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay
[PMID: 19138149]
MDA-MB-231 IC50
410 nM
Compound: 20
Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay
Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay
[PMID: 18954041]
MDA-MB-231 IC50
633 nM
Compound: 15, SM-125
Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay
Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay
[PMID: 21462933]
SK-OV-3 IC50
900 nM
Compound: 20
Growth inhibition of human SKOV3 cells after 4 days by WST8 assay
Growth inhibition of human SKOV3 cells after 4 days by WST8 assay
[PMID: 18954041]
分子量

476.61

Formula

C28H36N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SM-122 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SM-122874270-38-9SM122SM 122IAPApoptosisInhibitorinhibitorinhibit

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产品名称：
SM-122
目录号：
HY-155294
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