2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. SNAP-6201

SNAP-6201 是一种选择性 α1a 肾上腺素受体 (α1a adrenoceptor) 拮抗剂，Ki 值为 0.2 nM。SNAP-6201 对 α1b 和 α1d 肾上腺素受体的选择性比 α1a 受体高 1400 倍以上。在麻醉犬模型中，SNAP-6201 对尿道内压 (IUP) 具有极佳的选择性抑制作用。SNAP-6201 可用于良性前列腺增生 (BPH) 的研究。

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SNAP-6201

SNAP-6201 Chemical Structure

CAS No. : 252201-38-0

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SNAP-6201 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SNAP-6201 is a selective α1a adrenoceptor antagonist with a Ki of 0.2 nM. SNAP-6201 exhibits >1400-fold selectivity over α1b and α1d adrenoceptors. SNAP-6201 exhibits excellent selectively to inhibit intraurethral pressure (IUP) in the anesthetized dog model. SNAP-6201 can be used for benign prostatic hyperplasia (BPH) research[1].

IC50 & Target[1]

α1A-adrenergic receptor

0.2 nM (Ki)

α1B-adrenergic receptor

260 nM (Ki)

α1D-adrenergic receptor

350 nM (Ki)

rat α1A-adrenergic receptor

0.27 nM (Ki)

体外研究
(In Vitro)

SNAP-6201 (compound 103) 对重组大鼠、狗和人 α1a 肾上腺素受体表现出相似的结合亲和力，Ki 分别为 0.3、1.3 和 0.2 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SNAP-6201 相关抗体:
分子量

583.63

Formula

C30H35F2N5O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SNAP-6201 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNAP-6201252201-38-0SNAP6201SNAP 6201Adrenergic ReceptorBeta Receptorα1a adrenoceptorα1b adrenoceptorsα1d adrenoceptorsintraurethral pressureanesthetized dog modelbenign prostatic hyperplasiaInhibitorinhibitorinhibit

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