2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor Dopamine Receptor 5-HT Receptor
  4. SNAP8719 free base

SNAP8719 free base 是一种选择性 α1D- 肾上腺素受体 (α1D-adrenoceptor) 拮抗剂 (pKi = 8.89)。SNAP8719 对多巴胺 (dopamine) D2 受体、5-HT1A 受体和人克隆 α2a- 肾上腺素受体也具有亲和力，相应的 pKi 值分别为 5.98、6.47 和 <5.0。SNAP8719 可引起收缩反应呈浓度依赖性增加。

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SNAP8719 free base

SNAP8719 free base Chemical Structure

CAS No. : 255893-38-0

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SNAP8719 free base 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

查看 Dopamine Receptor 亚型特异性产品:

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

查看 5-HT Receptor 亚型特异性产品:

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SNAP8719 free base is a selective α1D-adrenoceptor antagonist (pKi = 8.89). SNAP8719 free base shows affinity for the dopamine D2-, 5-HT1A-, and the human clonal α2a-adrenoceptor, with pKi values of 5.98, 6.47, and <5.0, respectively. SNAP8719 free base causes a concentration-dependent increase in the twitch response[1].

IC50 & Target[1]

Alpha-1D adrenergic receptor

8.89 (pKi)

D2 Receptor

5.98 (pKi)

5-HT1A Receptor

6.47 (pKi)

Alpha-2A adrenergic receptor

<5.0 (pKi)

分子量

423.47

Formula

C22H28F3N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SNAP8719 free base 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNAP8719255893-38-0SNAP 8719SNAP-8719Adrenergic ReceptorDopamine Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptortwitch responseInhibitorinhibitorinhibit

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