2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Calcium Channel Proteasome Reactive Oxygen Species (ROS)
  4. SNJ-1945

SNJ-1945 是一种口服有效且能透过血脑屏障的钙蛋白酶抑制剂。SNJ-1945 可通过抑制 α-fodrin 水解，保护大鼠心脏免受停搏再灌注损伤。SNJ-1945 能抑制 VEGF 诱导的视网膜内皮细胞血管生成。SNJ-1945 也能保护 SH-SY5Y 细胞免受 MPP+ (HY-W008719) 和 Rotenone (HY-B1756) 诱导的损伤。SNJ-1945 在多发性硬化症小鼠模型中具有抗炎和神经保护的活性。SNJ-1945 可用于心血管、神经系统和炎症疾病的研究。

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SNJ-1945

SNJ-1945 Chemical Structure

CAS No. : 854402-59-8

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规格 价格 是否有货
5 mg ￥2025
询问价格 & 货期
10 mg ￥3240
询问价格 & 货期
25 mg ￥5100
询问价格 & 货期
50 mg 询价 询问价格 & 货期
100 mg 询价 询问价格 & 货期

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SNJ-1945 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SNJ-1945 is an orally active Calpain inhibitor that can cross the blood-brain barrier. SNJ-1945 protects rat hearts against cardiac arrest-reperfusion injury by inhibiting the hydrolysis of α-fodrin. SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells. SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ (HY-W008719) and Rotenone (HY-B1756). SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis. SNJ-1945 can be used for the research of cardiovascular, nervous system and inflammatory diseases[1][2][3][4].

分子量

491.58

Formula

C25H37N3O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SNJ-1945 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNJ-1945854402-59-8SNJ1945SNJ 1945Calcium ChannelProteasomeReactive Oxygen Species (ROS)Ca2+ channelsCa channelsHRMECproliferative retinopathymacular degenerationSH-SY5YMSPDEAEInhibitorinhibitorinhibit

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