2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. SNX3-IN-1

SNX3-IN-1 是一种分选连接蛋白 3 (SNX3) 抑制剂。SNX3-IN-1 降低 SNX3 蛋白表达，抑制 SNX3 介导的 Wnt/β-catenin 信号通路激活。SNX3-IN-1 抑制肺纤维化相关细胞的增殖与迁移，并降低纤维化标志物 α-SMA 和 COL-1 的表达。SNX3-IN-1 可用于肺纤维化相关研究。

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SNX3-IN-1

SNX3-IN-1 Chemical Structure

CAS No. : 2344793-72-0

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SNX3-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Wnt 亚型特异性产品:

查看所有亚型
Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SNX3-IN-1 is a sorting nexin 3 (SNX3) inhibitor. SNX3-IN-1 reduces SNX3 protein expression and inhibits SNX3-mediated activation of the Wnt/β-catenin signaling pathway. SNX3-IN-1 inhibits the proliferation and migration of pulmonary fibrosis-related cells, and decreases the expression of fibrosis markers α-SMA and COL-1. SNX3-IN-1 can be used in research related to pulmonary fibrosis[1].

体外研究
(In Vitro)

SNX3-IN-1 (Compound LC4) 可抑制过表达 SNX3 的成纤维细胞增强的迁移能力[1]。
SNX3-IN-1 可抑制细胞中由 SNX3 诱导的 β-catenin 积累及核定位[1]。
SNX3-IN-1 (10 μM) 可抑制 TGF-β1 诱导的 AT2 细胞和成纤维细胞中 α-SMA 的表达，从而减少纤维化激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SNX3-IN-1 相关抗体:
体内研究
(In Vivo)

SNX3-IN-1 (Compound LC4) (10 mg/kg; 气管给药; 一周一次共 3 周) 可有效改善肺纤维化小鼠模型中的 Wnt/β-catenin 通路激活、肺功能损伤与纤维化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J Snx3-cTg mice (2 months old, male and female; spontaneous pulmonary fibrosis model); C57BL/6J N-Tg mice (2 months old, male and female; bleomycin-induced pulmonary fibrosis model)[1]
Dosage: 10 mg/kg
Administration: intratracheal; once weekly; 3 weeks
Result: Mitigated Bleomycin (BLM) (HY-108345)-induced pulmonary functional injury, reduced fibrosis areas, lowered β-catenin protein levels, and decreased hydroxyproline concentration in N-Tg mice.
Reversed fibrotic effects associated with SNX3 overexpression in Snx3-cTg mice, including reducing lung injury, fibrosis areas, and β-catenin levels.
Demonstrated therapeutic efficacy equivalent to positive control pirfenidone in inhibiting BLM-induced pulmonary fibrosis.
分子量

396.43

Formula

C23H24O6
CAS 号
Sequence

Arg-His-Arg-Thr-Pro-Met-Phe-Tyr-Gly-Leu-Met-NH2
Sequence Shortening

RHRTPMFYGLM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SNX3-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNX3-IN-12344793-72-0Wntβ-cateninBeta cateninSNX3mouse modelsfibroblastsCOL-1Sorting nexin 3α-SMAAT2 cellspulmonary fibrosisWnt/β-catenin signalingInhibitorinhibitorinhibit

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