Sodium thiosulfate (99%, water≤1.0%)  (Synonyms: Sodium hyposulfite (99%, water≤1.0%))

Sodium thiosulfate is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease^{[1][2][3][4][5][6][7][8][9]}.

Sodium thiosulfate (1.2-120 μM；48 h) 不影响 MCF-7 活力^[1]。
Sodium thiosulfate (3 mM；8 h) 可刺激人脐静脉内皮细胞 (HUVEC) 增殖^[2]。
Sodium thiosulfate (0.2-25 mM；1-7 天) 剂量依赖性地抑制小鼠关节软骨细胞的矿化^[3]。
Sodium thiosulfate (1-500 μM；8 h) 可降低 LPS/IFNγ 诱导的小胶质细胞中 TNFα 和 IL-6 的释放^[4]。
Sodium thiosulfate (0.1-10 mM；48 h) 不会减弱 Doxorubicin (HY-15142A) 在人乳腺癌 MCF-7 细胞和人宫颈癌 HeLa 细胞中的抗癌活性^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium thiosulfate (0.5-1 g/kg/天；通过水瓶口服；每周更换三次) 可促进野生型 C57BL/6JRj 小鼠和高胆固醇血症 LDLR^-/- 小鼠的后肢缺血诱导的血管重建和肌肉恢复，增加毛细血管密度，减少肌肉损伤^[2]。
Sodium thiosulfate (0.4 g/kg；腹腔注射；每周三次) 在雌性 C57BL/6 小鼠半月板切除术诱发的骨关节炎模型中可减少关节周围新生钙化沉积物的体积和晶体含量，减轻胫骨和股骨软骨损伤和蛋白多糖丢失，并显示新生矿化结构体积与胫骨软骨退化评分之间显著正相关的现象^[3]。
Sodium thiosulfate (2 g/kg；腹腔注射，LPS 刺激后 0 和 12 h；0.5 g/kg；静脉注射，CLP 后 10 min) 可通过抑制肺部炎症、降低肺通透性和抑制 NFκB 活化来减轻雄性 C57BL6J 小鼠中 LPS 或 CLP 诱导的急性肺损伤^[5]。
Sodium thiosulfate (2-3 g/kg；每日一次) 通过 Wnt/β-catenin 信号通路抑制移植 B16 细胞的裸鼠中的肿瘤生长和 EMT 过程^[8]。
Sodium thiosulfate (100-750 mg/kg；腹腔注射) 可通过降低 IL-1β、COX-2、Iba-1 和 TSPO 水平来减轻雌性 C57BL/6J 小鼠全身性脂多糖给药引起的脑炎症^[9]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

158.11

Na₂S₂O₃

7772-98-7

固体

White to off-white

硫代硫酸钠 (99%, 水分≤1.0%)

Room temperature in continental US; may vary elsewhere.

Store at room temperature, keep dry and cool

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Ota A, et al. The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death. Pharmacol Rep. 2021 Jun;73(3):847-857.  [Content Brief]

  [2]. Macabrey D, et al. Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization. Front Cardiovasc Med. 2022 Oct 3;9:965965.  [Content Brief]

  [3]. Nasi S, et al. Sodium Thiosulfate Prevents Chondrocyte Mineralization and Reduces the Severity of Murine Osteoarthritis. PLoS One. 2016 Jul 8;11(7):e0158196.  [Content Brief]

  [4]. Lee M, et al. Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases. J Neuroinflammation. 2016 Feb 8;13:32.  [Content Brief]

  [5]. Sakaguchi M, et al. Sodium thiosulfate attenuates acute lung injury in mice. Anesthesiology. 2014 Dec;121(6):1248-57.  [Content Brief]

  [6]. Mizuta Y, et al. Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice. Life Sci. 2020 Sep 15;257:118074.  [Content Brief]

  [7]. Bijarnia RK, et al. Sodium thiosulfate ameliorates oxidative stress and preserves renal function in hyperoxaluric rats. PLoS One. 2015 Apr 30;10(4):e0124881.  [Content Brief]

  [8]. Wang D, et al. Sodium thiosulfate inhibits epithelial-mesenchymal transition in melanoma via regulating the Wnt/β-catenin signaling pathway. J Dermatol Sci. 2023 Feb;109(2):89-98.  [Content Brief]

  [9]. Acero G, et al. Sodium thiosulphate attenuates brain inflammation induced by systemic lipopolysaccharide administration in C57BL/6J mice. Inflammopharmacology. 2017 May 19.  [Content Brief]