2. Metabolic Enzyme/Protease
  3. MMP
  4. Solimastat

Solimastat (BB-3644) 是一种强效的金属蛋白酶 (MMP) 抑制剂，可抑制细胞表面组成型及抗体刺激下的 CD30 蛋白的脱落，其 IC50 为 180 nM。Solimastat 能增强抗 CD30 单克隆抗体 Ki-3 在细胞表面的滞留时间，并促进其内化。Solimastat 还可增强抗 Ki-3.dgA 对 CD30+ L540 细胞的细胞毒性作用。Solimastat 可用于 CD30 阳性的恶性肿瘤的研究。

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Solimastat

Solimastat Chemical Structure

CAS No. : 226072-63-5

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Solimastat 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Solimastat (BB-3644) is a potent metalloproteinase (MMP) inhibitor that blocks constitutive and antibody-stimulated CD30 shedding from cell surfaces with an IC50 of 180 nM. Solimastat enhances persistence of anti-CD30 antibody Ki-3 on cells and favors its internalization. Solimastat enhances cytotoxic activity of Ki-3.dgA towards CD30+ L540 cells. Solimastat can be used for the research of CD30+ malignancies[1].

体外研究
(In Vitro)

Solimastat (0-105 nM，10 分钟) 以剂量依赖性方式强力抑制 PMA (HY-18739) 诱导的 Karpas 299 细胞中 CD30 的脱落[1]。
Solimastat (5 μM；12 小时) 显著增强 Ki-3 单克隆抗体在 Karpas 299 细胞中的内化及表面滞留，但对抗体内吞过程本身无影响[1]。
Solimastat (5 μM；48 小时) 可增强 Ki-3.dgA 免疫毒素对 L540 细胞的细胞毒性作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solimastat 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: CD30+ L540 and CD30- HD-MyZ cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Had no influence on the cell viability of L540 and HD-MyZ cells alone.
Increased cytotoxic activity of Ki-3.dgA immunotoxin against L540 cells, with IC50 shifts from 0.34 nM to 18.3 nM.
分子量

408.50

Formula

C20H32N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Solimastat 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Solimastat226072-63-5BB-3644BB3644BB 3644MMPMatrix metalloproteinasesCD30 sheddingmetalloproteinase inhibitorCD30+ Hodgkin-derived cellsCD30anti-CD30 antibody Ki-3TACEKarpas 299 cellsL540 cellsanti-CD30 ricin A-chain immunotoxin Ki-3.dgACD30+ malignanciesInhibitorinhibitorinhibit

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产品名称：
Solimastat
目录号：
HY-180412
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