2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Farnesyl Transferase Apoptosis DNA/RNA Synthesis
  4. SQS-IN-1

SQS-IN-1 是一种角鲨烯合酶 (SQS) 抑制剂。SQS-IN-1 对多种小鼠和人类肺癌细胞系均表现出强效且广谱的抗增殖作用。SQS-IN-1 抑制 DNA 复制和细胞周期，导致线粒体超极化并诱导细胞凋亡 (apoptosis)。SQS-IN-1 抑制细胞迁移和侵袭。SQS-IN-1 可用于肺癌研究。

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SQS-IN-1

SQS-IN-1 Chemical Structure

CAS No. : 2306302-57-6

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SQS-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer[1].

体外研究
(In Vitro)

SQS-IN-1 (Compound 2) (0.1 nM-100 μM, 24-72 h) 可抑制多种肺癌细胞系增殖，包括 LLCOVA 细胞、NSCLC 细胞系 (H1299 和 H358) 以及 B16 黑色素瘤细胞，72 小时时的 TC50 分别为 3.21 nM、1.6 μM、0.55 μM 和 0.21 μM[1]。
SQS-IN-1 (10 and 0.1 μM, 24 h) 可诱导 A549 细胞发生 G0/G1 期阻滞，抑制 LLC-OVA 细胞的 DNA 复制[1]。
SQS-IN-1 (0.1 μM, 24 h) 可诱导 LLC-OVA 细胞凋亡，并有效抑制癌细胞的转移能力[1]。
SQS-IN-1 (0-10 μM) 以剂量依赖性方式引起 LLC-OVA 细胞中的线粒体超极化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SQS-IN-1 相关抗体:

Cell Cycle Analysis[1]

Cell Line: A549 and LLC-OVA cells
Concentration: 10 μM (A549) and 0.1 μM (LLC-OVA)
Incubation Time: 24 h
Result: Significantly reduced the proportion of cells in the S phase and the G2 phase, resulting in the accumulation of cells in the G0/G1 phase in A549 cells.
Inhibited DNA replication and the cell cycle progression in LLC-OVA.

Apoptosis Analysis[1]

Cell Line: LLC-OVA cells
Concentration: 0.1 μM
Incubation Time: 24 h
Result: Significantly increased the percentage of cells in the early apoptotic stage.

Cell Migration Assay [1]

Cell Line: LLC-OVA cells
Concentration: 0.1 μM
Incubation Time: 24 h
Result: Reduced the wound closure rate of LLC-OVA cells by approximately 23%.

Cell Invasion Assay[1]

Cell Line: LLC-OVA cells
Concentration: 0.1 μM
Incubation Time: 24 h
Result: Reduced the invasive ability of LLC-OVA cells by 25%.
分子量

503.39

Formula

C24H27BrN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SQS-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SQS-IN-12306302-57-6Farnesyl TransferaseApoptosisDNA/RNA SynthesisFtaseSqualene Synthase (SQS)inhibitorscholesterollung cancerInhibitorinhibitorinhibit

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