2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. STA-9584

STA-9584 是一种强效的血管破坏剂 (VDA)，靶向微管蛋白 (tubulin)。STA-9584在小鼠异种移植模型中，通过选择性靶向肿瘤中心和周边的微血管，表现出强大的抗肿瘤活性。STA-9584 可用于前列腺癌和乳腺癌的研究。

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STA-9584

STA-9584 Chemical Structure

CAS No. : 906481-23-0

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STA-9584 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STA-9584 is a potent vascular disrupting agent (VDA) that targets tubulin. STA-9584 exhibits potent antitumor activity in mouse xenograft model by selectively targeting microvasculature at both the center and periphery of tumors. STA-9584 can be used for research in prostate and breast cancer[1].

体内研究
(In Vivo)

STA-9584 (4.5 mg/kg，静脉注射，每周一次，持续 2-3 周) 通过选择性地破坏肿瘤中心和外周的微血管，在小鼠前列腺和乳腺癌异种移植模型中诱导显著的肿瘤消退[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (7-12 weeks old) subcutaneously implanted with EMT6 cells[1]
Dosage: 4.5 mg/kg
Administration: i.v., weekly for 2 weeks
Result: Completely blocked blood flow in highly perfused tumor subregions within 4 h of drug administration.
Completely arrested tumor growth over this period with a single dose for 24 h.
Exhibited far more extensive cellular destruction throughout the entire tumor, including areas of fibrosis and dramatically reduced viable rim or surviving tumor zones.
Resulted in no detectable viable rim tissue in many tumor sections.
Increased microvasculature destruction and consequent apoptosis in peripheral regions of tumors.
Induced widespread disruption of tumor microvessels, characterized by decreased, patchy CD31 expression, loss of integrity, and thrombosis.
Decreased CD31 endothelial cells in the viable rim by 77%.
Animal Model: Female BALB/c nude mice (7-12 weeks old) subcutaneously implanted with PC-3 cells[1]
Dosage: 4.5 mg/kg
Administration: i.v., weekly for 3 weeks
Result: Induced significantly tumor regression (40%) compared with the control group.
Was well tolerated with minimal loss of body weight during the course of treatment.
Animal Model: Female CB-17/ Icr-Prkdcscid (SCID) mice (7-12 weeks old) subcutaneously implanted with MDA-MB-231 cells[1]
Dosage: 4.5 mg/kg
Administration: i.v., weekly for 3 weeks
Result: Resulted in 60% tumor regression.
分子量

540.01

Formula

C28H30ClN3O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STA-9584 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STA-9584906481-23-0STA9584STA 9584Microtubule/TubulinVDAxenograftmicrovasculatureprostatebreastPC-3EMT6MDA-MB-231BALB/cCB-17/Icr-Prkdc scid (SCID)Inhibitorinhibitorinhibit

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目录号：
HY-111170
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