2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. Stearidonic acid

Stearidonic acid  (Synonyms: 6Z,9Z,12Z,15Z-Octadecatetraenoic acid)

目录号: HY-113120
一键复制产品信息 纯度: 98.0%
COA 产品使用指南 技术支持

Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) 是一种具有口服活性的多不饱和脂肪酸，被发现存在于黑加仑籽油 (blackcurrant seed oil) 中。Stearidonic acid 可抑制 5-脂氧合酶 (5-lipoxygenase) 并减少白三烯和 5-HETE 的合成。Stearidonic acid 可提高红细胞中二十碳五烯酸 (EPA) 的含量。Stearidonic acid 可用于代谢疾病的研究。

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Stearidonic acid

Stearidonic acid Chemical Structure

CAS No. : 20290-75-9

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1 mg (36.18 mM * 100 μL in Ethanol) ￥1350
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5 mg (36.18 mM * 500 μL in Ethanol) ￥4050
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10 mg (36.18 mM * 1 mL in Ethanol) 现货 询价

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Stearidonic acid 相关抗体

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查看 Lipoxygenase 亚型特异性产品:

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5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease[1][2].

IC50 & Target[1]

5-LOX

 

体外研究
(In Vitro)

Stearidonic acid (10-20 μM; 30 min) 可抑制分离的人白细胞中 5-脂氧合酶通路产物的生成，其中 20 μM 可使白三烯合成减少 50%，10 μM 可使白三烯合成减少 35%[1]。
Stearidonic acid (10-100 μM; 30 min) 可在分离的人白细胞中剂量依赖性抑制 5-HETE 生成，其中 100 μM 可使 5-HETE 水平降低 45%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Stearidonic acid 相关抗体:
体内研究
(In Vivo)

Stearidonic acid (1% in diet；口服；持续 21 天) 喂食大鼠后，其血浆 EPA 的富集程度是等量 α-Linolenic acid (HY-N0728) 饮食的 2 倍[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat (healthy)[2]
Dosage: 1% of diet
Administration: Oral; daily; 21 days
Result: Produced a two-fold greater enrichment in plasma eicosapentaenoic acid (EPA) compared to rats fed an α-Linolenic acid-containing diet of the same concentration.
分子量

276.41

Formula

C18H28O2
CAS 号
性状

液体

颜色

Colorless to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: 98.30%

COA (275 KB)

产品使用指南 (1538 KB)
参考文献

Stearidonic acid 相关分类

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Keywords:

Stearidonic acid20290-75-96Z,9Z,12Z,15Z-Octadecatetraenoic acidLipoxygenaseLOX5-lipoxygenaseα-linolenic acidleukocytesEPAInhibitorinhibitorinhibit

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