2. Cell Cycle/DNA Damage Cytoskeleton Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Stem Cell/Wnt Metabolic Enzyme/Protease Apoptosis Epigenetics
  3. Microtubule/Tubulin FAK MEK ERK MMP Caspase PARP Apoptosis MDM-2/p53
  4. STK899704

STK899704 是一种微管蛋白 (tubulin) 聚合抑制剂。STK899704 对多种癌细胞系具有广谱抑制作用，IC50 值在 0.2-1.0 μM 范围内。STK899704 破坏有丝分裂纺锤体结构，诱导 G2/M 期细胞周期阻滞。STK899704 通过下调 FAK-MEK-ERK 信号通路，抑制 MMP-2 和 MMP-9 的表达和活性，从而抑制 HT29 细胞的迁移能力。STK899704 激活 caspase-3/7/8/9,并导致 PARP cleavage，诱发细胞凋亡 (apoptosis)。STK899704 通过 p53 通路诱导细胞衰老。STK899704 可用于皮肤癌、肺癌、结肠癌等癌症研究。

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STK899704

STK899704 Chemical Structure

CAS No. : 1578247-29-6

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STK899704 相关抗体

Top Publications Citing Use of Products

查看 MEK 亚型特异性产品:

查看所有亚型
MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

查看 MMP 亚型特异性产品:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STK899704 is a tubulin polymerization inhibitor. STK899704 exhibits broad-spectrum inhibitory activity against various cancer cell lines with IC50 values ​​ranging from 0.2 to 1.0 μM. STK899704 disrupts the mitotic spindle structure, inducing G2/M phase cell cycle arrest. STK899704 inhibits the migration ability of HT29 cells by downregulating the FAK-MEK-ERK signaling pathway, thereby suppressing the expression and activity of MMP-2 and MMP-9. STK899704 activates caspase-3/7/8/9, leading to PARP cleavage and inducing apoptosis. STK899704 induces cellular senescence through the p53 pathway. STK899704 can be used in research on skin cancer, lung cancer, colon cancer, and other cancers[1][2][3].

IC50 & Target[1][2][3]

ERK

 

MMP-2

 

MMP-9

 

Caspase-3

 

Caspase-9

 

Caspase-8

 

Caspase-7

 

MEK

 

分子量

453.49

Formula

C27H23N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STK899704 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STK8997041578247-29-6STK 899704STK-899704Microtubule/TubulinFAKMEKERKMMPCaspasePARPApoptosisMDM-2/p53PTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesMatrix metalloproteinasespoly ADP ribose polymerase lung carcinomasenescencecancer therapycell cycle arrestp53Inhibitorinhibitorinhibit

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