1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Sudemycin D6

Sudemycin D6 是一种具有强效抗肿瘤活性的 pre-mRNA 剪接调节剂。Sudemycin D6 可改变 DUSP11SRRM1 前体 mRNA 的剪接位点利用情况。Sudemycin D6 可降低表达突变型 U2AF1 的造血细胞的存活率并改变其细胞周期。Sudemycin D6 可减弱 U2AF1(S34F) 转基因小鼠中突变型 U2AF1 诱导的造血祖细胞扩增。Sudemycin D6 可用于癌症研究。

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Sudemycin D6

Sudemycin D6 Chemical Structure

CAS No. : 1510837-67-8

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  • 生物活性

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生物活性

Sudemycin D6 is a pre-mRNA splicing modulator with potent antitumour activity. Sudemycin D6 changes splice site usage of the DUSP11 and SRRM1 pre-mRNA. Sudemycin D6 reduces survival and alters cell cycle in haematopoietic cells expressing mutant U2AF1. Sudemycin D6 attenuates mutant U2AF1-induced haematopoietic progenitor cell expansion in U2AF1(S34F) transgenic mice. Sudemycin D6 can be used for cancer research[1][2].

分子量

474.63

Formula

C27H42N2O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Sudemycin D6
目录号:
HY-139499
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