2. Epigenetics
  3. SF3B1
  4. Sudemycin E

Sudemycin E 是 FR901464 (HY-16212) 的类似物。Sudemycin E 通过结合 U2 小核核糖核蛋白 (snRNP) 组分 SF3B1，可引发可逆的可变剪接改变和染色质修饰异常，进而导致癌细胞死亡。Sudemycin E 具有抗肿瘤的活性，可用于肿瘤的研究。

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Sudemycin E

Sudemycin E Chemical Structure

CAS No. : 1197054-49-1

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Sudemycin E 相关抗体

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  • 生物活性

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生物活性

Sudemycin E is an analog of FR901464 (HY-16212). Sudemycin E can induce reversible changes in alternative splicing and abnormalities in chromatin modifications by binding to SF3B1, a component of the U2 small nuclear ribonucleoprotein (snRNP), thereby leading to the death of cancer cells. Sudemycin E has anti-tumor activity and can be used in tumor research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
JeKo-1 IC50
150 nM
Compound: 26
Cytotoxicity against human JeKo1 cells after 72 hrs by XTT assay
Cytotoxicity against human JeKo1 cells after 72 hrs by XTT assay
[PMID: 19877647]
JeKo-1 IC50
220 nM
Compound: 19p
Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
[PMID: 24325474]
分子量

491.62

Formula

C27H41NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sudemycin E 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sudemycin E1197054-49-1SF3B1Splicing Factor 3b Subunit 1FR901464snRNPtumorcancerInhibitorinhibitorinhibit

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