2. Neuronal Signaling Apoptosis
  3. Sigma Receptor Apoptosis
  4. SV119 hydrochloride

SV119 hydrochloride 是一种 sigma-2 配体，Ki 值为 5.2 nM。SV119 hydrochloride 增强了药物在癌细胞质膜上的高效运输。dm-Erastin 与 SV119 hydrochloride 的结合成功克服了在胰腺癌中观察到的内化障碍，同时保留了 Erastin (HY-15763) 的固有抗肿瘤活性。此外，SV119 hydrochloride 对三阴性乳腺癌 (TNBC) 细胞显示出细胞毒性作用，并诱导凋亡 (apoptosis)。

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SV119 hydrochloride

SV119 hydrochloride Chemical Structure

CAS No. : 913816-12-3

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Other Forms of SV119 hydrochloride:

SV119 hydrochloride 相关抗体

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  • 生物活性

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生物活性

SV119 hydrochloride is a sigma-2 ligand with a Ki value of 5.2 nM. SV119 hydrochloride enhances the efficient transport of drugs across the plasma membrane of cancer cells. The conjugation of dm-Erastin with SV119 hydrochloride successfully overcomes the internalization barrier observed in pancreatic cancer, while preserving the inherent anti-tumor activity of Erastin (HY-15763). Additionally, SV119 hydrochloride demonstrates cytotoxic effects on triple-negative breast cancer (TNBC) cells and induces apoptosis[1][2].

分子量

476.48

Formula

C23H39Cl2N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SV119 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

SV119913816-12-3SV 119SV-119Sigma ReceptorApoptosisInhibitorinhibitorinhibit

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产品名称：
SV119 hydrochloride
目录号：
HY-177345A
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