2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. T 588

T 588 是一种具有口服活性的神经保护剂。T 588 能够增加额叶皮质和海马体中乙酰胆碱的释放，并改善认知功能障碍。T 588 可以保护小脑颗粒细胞免受谷氨酸的神经毒性影响。T 588 可用于神经系统疾病的研究，如阿尔茨海默病。

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T 588

T 588 Chemical Structure

CAS No. : 142935-03-3

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T 588 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

T 588 is an orally active neuroprotective agent. T 588 can increase acetylcholine release from the frontal cortex and hippocampus and meliorate cognitive dysfunction. T 588 can protect cerebellar granule cells from glutamate neurotoxicity. T 588can be used for the research of neurological disease, such as Alzheimer's disease[1].

体内研究
(In Vivo)

T-588 (3-30 mg/kg，口服，每日一次，持续 4 周) 在摇摆小鼠中显示出神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wobbler mice (model of motoneuron disease (MND))[1]
Dosage: 3, 10 and 30 mg/kg
Administration: Orally administration, daily for 4 weeks
Result: Potentiated grip strength, attenuated forelimb contracture and increased the weight of the biceps muscles.
Retarded denervation muscle atrophy and elevated activities of choline acetyltransferase (ChAT) or lactate dehydrogenase in the biceps muscles.
分子量

329.89

Formula

C16H24ClNO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

T 588 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T 588142935-03-3T588T-588nAChRNicotinic acetylcholine receptorsAlzheimer's diseaseneuroprotectiveacetylcholineglutamateWobbler miceInhibitorinhibitorinhibit

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