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  4. Tallimustine

Tallimustine (FCE 24517)，一种 distamycin-A 衍生物，是一种抗癌剂。

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Tallimustine

Tallimustine Chemical Structure

CAS No. : 115308-98-0

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Tallimustine 的其他形式现货产品:

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Other Forms of Tallimustine:

Tallimustine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent[1][2][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
L1210 IC50
208 ng/mL
Compound: 1h
Compound was tested in vitro for cytotoxicity after 48 hr of continuouse exposure against L1210 murine leukemia cells
Compound was tested in vitro for cytotoxicity after 48 hr of continuouse exposure against L1210 murine leukemia cells
10.1016/S0960-894X(97)10121-4
L1210 IC50
48.9 nM
Compound: tallimustine (TAM)
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)
[PMID: 15115402]
L1210 IC50
50.3 ng/mL
Compound: 1a
Compound was tested in vitro for cytotoxicity after 48 hr of continuouse exposure against L1210 murine leukemia cells
Compound was tested in vitro for cytotoxicity after 48 hr of continuouse exposure against L1210 murine leukemia cells
10.1016/S0960-894X(97)10121-4
L1210 IC50
55.3 nM
Compound: tallimustine (TAM)
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells
[PMID: 15115402]
体外研究
(In Vitro)

Tallimustine (0.1-10 μM, 4 h) induces damage to purified SV40 DNA[1].
Tallimustine (72 h ) shows cytotoxicity in CEM Cells, with an IC50 of 3.5 nM[1].
Tallimustine (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells[2].
Tallimustine (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells[2].
Tallimustine (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tallimustine 相关抗体:

Cell Viability Assay[2]

Cell Line: K562 cells
Concentration: 25 and 100 nM
Incubation Time: 4 days
Result: Inhibited cell proliferation.
体内研究
(In Vivo)

Tallimustine (3 mg/kg, i.p.) shows antileukaemic activity in L1210 tumor bearing mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: L1210 tumor bearing mice[2].
Dosage: 3 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Prolonged the survival of mice.
Clinical Trial
分子量

697.61

Formula

C32H38Cl2N10O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tallimustine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tallimustine115308-98-0FCE 24517FCE24517FCE-24517Drug DerivativeDrug derivativeAMLleukemiaK562L1210Inhibitorinhibitorinhibit

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