2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway
  3. FGFR ERK
  4. TCB-32 hydrochloride

TCB-32 (Compound I-1) hydrochloride 是一种 FGFR1 激动剂，其 EC50 为 0.88 μM。TCB-32 hydrochloride 通过激活 FGFR1 及其下游 ERK 1/2 来促进细胞增殖，且具有优异的热稳定性。TCB-32 hydrochloride 可替代 bFGF 用于无血清细胞培养基。TCB-32 hydrochloride 可用于组织修复和伤口愈合相关疾病 (如银屑病和湿疹) 研究。

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TCB-32 hydrochloride

TCB-32 hydrochloride Chemical Structure

CAS No. : 169764-95-8

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Other Forms of TCB-32 hydrochloride:

TCB-32 hydrochloride 相关抗体

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TCB-32 (Compound I-1) hydrochloride is a FGFR1 agonist with an EC50 of 0.88  μM. TCB-32 hydrochloride significantly increases cell proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK 1/2 with excellent thermal stability. TCB-32 hydrochloride can replace bFGF in serum-free cell culture media. TCB-32 hydrochloride can be used for tissue repair and wound healing related diseases like psoriasis and eczema research[1][2].

IC50 & Target[1][2]

FGFR1

0.88 μM (EC50)

ERK1

 

ERK2

 

分子量

854.62

Formula

C32H44Cl4N18O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TCB-32 hydrochloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCB-32169764-95-8TCB32TCB 32FGFRERKFibroblast growth factor receptorExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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