2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. TDPAM02

TDPAM02 是 AMPA 受体 GluA2 的一种正性变构调节剂。TDPAM02 能特异性结合 GluA2 的配体结合域 (LBD)，对 GluA2 flop 亚型的 IC50 值为 1.4 nM。TDPAM02 可稳定 GluA2 受体的激活构象，延缓受体失活或脱敏过程，维持中枢神经系统中快速的兴奋性突触传递。

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TDPAM02

TDPAM02 Chemical Structure

CAS No. : 2231101-34-9

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TDPAM02 相关抗体

Top Publications Citing Use of Products

查看 iGluR 亚型特异性产品:

查看所有亚型
AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TDPAM02 is a positive allosteric modulator of AMPA receptor GluA2. TDPAM02 can specifically bind to the ligand-binding domain (LBD) of GluA2 and shows an IC50 of 1.4 nM for the GluA2 flop subtype. TDPAM02 can stabilize the activated conformation of GluA2 receptors, delay the receptor deactivation or desensitization process, maintaining the rapid excitatory synaptic transmission in the central nervous system[1].

IC50 & Target[1]

AMPA Receptor

 

分子量

474.59

Formula

C22H26N4O4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TDPAM02 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDPAM022231101-34-9TDPAM 02TDPAM-02iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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产品名称：
TDPAM02
目录号：
HY-165475
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