2. Cell Cycle/DNA Damage Apoptosis
  3. Telomerase Apoptosis
  4. Telomerase-IN-9

Telomerase-IN-9 是一种高效且选择性的端粒酶 (telomerase) 抑制剂。Telomerase-IN-9 通过与 hTERT 结合显著降低端粒酶活性，从而导致端粒酶功能下降。Telomerase-IN-9 可诱导细胞凋亡 (apoptosis) 并抑制克隆形成。Telomerase-IN-9 可降低肿瘤负荷，恢复抗氧化平衡，并在 Benzo[a]pyrene (HY-107377) 诱导的肺癌小鼠模型中保护肺部结构。Telomerase-IN-9 可用于肺癌的研究。

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Telomerase-IN-9

Telomerase-IN-9 Chemical Structure

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Telomerase-IN-9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telomerase-IN-9 is a potent and selective telomerase inhibitor. Telomerase-IN-9 significantly reduces telomerase activity by binding to hTERT, leading to decreased telomerase function. Telomerase-IN-9 induces apoptosis and inhibits colony formation. Telomerase-IN-9 reduces tumor burden, restores antioxidantbalance, and preserves lung architecture in a Benzo[a]pyrene (HY-107377)-induced lung cancer mouse model. Telomerase-IN-9 can be used for the research of lung cancer[1].

体外研究
(In Vitro)

Telomerase-IN-9 (compound 28) (48 小时) 对 A549、MDA-MB-231、NCI-H460 细胞表现出强效且选择性的细胞毒性，IC50 分别为 0.043、0.926 和 1.08 μM，而对 Vero 细胞的细胞毒性较低，IC50 > 25 μM[1]。
Telomerase-IN-9 (5-10 μM，48 小时) 在 A549 细胞中以计量依赖的方式诱导细胞凋亡[1]。
Telomerase-IN-9 (10 μM) 显著抑制 A549 细胞中的端粒酶活性，倍数变化为 0.535[1]。
Telomerase-IN-9 (3.75-25 μM，12 天) 以浓度依赖性的方式抑制 A549 细胞集落形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Telomerase-IN-9 相关抗体:

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 5, 10 μM
Incubation Time: 48 h
Result: Induced cell death in a dose-dependent manner.
Reduced viability to 76.2% and 62.6% at 5 μM and 10 μM, respectively.
Induced late apoptosis reaching up to 23.1%.

Cell Proliferation Assay[1]

Cell Line: A549 cells
Concentration: 3.75, 6.25, 12.5, 25 μM
Incubation Time: 12 days
Result: Demonstrated marked inhibition of colony growth, particularly at higher concentrations (12.5 and 25 μM), where the reduction was statistically significant compared to the control.
分子量

388.49

Formula

C22H20N4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Telomerase-IN-9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telomerase-IN-9TelomeraseApoptosishTERT inhibition,TelomeraseInhibitorinhibitorinhibit

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产品名称：
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目录号：
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