2. Cell Cycle/DNA Damage Apoptosis
  3. G-quadruplex DNA/RNA Synthesis Apoptosis
  4. Telomeric G4s ligand 1

Telomeric G4s ligand 1 是一种端粒 G-四链体配体，可稳定端粒 G4 并诱导 R 环形成，从而导致 DNA 损伤反应。Telomeric G4s ligand 1 诱导肿瘤细胞凋亡并引发免疫原性细胞死亡 (ICD)。

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Telomeric G4s ligand 1

Telomeric G4s ligand 1 Chemical Structure

CAS No. : 3047091-81-3

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规格 价格 是否有货 数量
5 mg ￥595
In-stock
10 mg ￥935
In-stock
25 mg ￥1836
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50 mg ￥2932
In-stock
100 mg ￥4675
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Telomeric G4s ligand 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
4.6 μM
Compound: R1
Cytotoxicity against mouse 4T1 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against mouse 4T1 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
[PMID: 38805936]
MCF-10A IC50
5.8 μM
Compound: R1
Cytotoxicity against human MCF-10A cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against human MCF-10A cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
[PMID: 38805936]
MCF7 IC50
3.6 μM
Compound: R1
Cytotoxicity against human MCF7 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against human MCF7 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
[PMID: 38805936]
MDA-MB-231 IC50
1.7 μM
Compound: R1
Cytotoxicity against human MDA-MB-231 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against human MDA-MB-231 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
[PMID: 38805936]
U2OS IC50
3 μM
Compound: R1
Cytotoxicity against human U2OS cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against human U2OS cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
[PMID: 38805936]
体外研究
(In Vitro)

Telomeric G4s ligand 1（化合物 R1；1-4 μM；24 小时）可稳定 G4 并在 MDA-MB-231 细胞的端粒区域诱导 R 环结构，从而引发 DNA 损伤反应、G2/M 期细胞周期停滞、细胞凋亡和抗增殖[1]。
Telomeric G4s ligand 1 可引发肿瘤细胞的免疫原性细胞死亡 (ICD)，从而促进骨髓衍生树突状细胞 (BMDC) 的成熟[1]。 MDA-MB-231 cells 1 μM, 2 μM, 4 μM 24 h Increased the levels of DNA damage-related proteins, such as γH2AX and replication protein A subunit.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Telomeric G4s ligand 1 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1 μM, 2 μM, 4 μM
Incubation Time: 24 h
Result: Induced cell cycle arrest in G2/M phase and apoptosis.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1 μM, 2 μM, 4 μM
Incubation Time: 24 h
Result: Increased the levels of DNA damage-related proteins, such as γH2AX and replication protein A subunit.
体内研究
(In Vivo)

Telomeric G4s ligand 1（化合物 R1；10 mg/kg；腹腔注射；每隔一天，持续 14 天）通过免疫调节作用显著降低肿瘤负担，包括乳腺癌小鼠模型中肿瘤中 CD4+ 和 CD8+ T 细胞的增加以及血清中细胞因子水平的增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-week-old female BALB/c mice injected 4T1 cells[1]
Dosage: 10 mg/kg
Administration: ip; every other day for 14 days
Result: Exhibited the ability to lengthen the survival time of tumor-bearing mice, and resulted in DNA damage and apoptosis in vivo.
分子量

550.66

Formula

C31H37F3N6
CAS 号
性状

固体

颜色

Orange to red

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 16.67 mg/mL (30.27 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8160 mL 9.0800 mL 18.1600 mL
5 mM 0.3632 mL 1.8160 mL 3.6320 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
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浓度
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

V1

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浓度 (final)

C2

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体积 (final)

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动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

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每只动物的给药体积

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动物数量

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由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Telomeric G4s ligand 1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8160 mL 9.0800 mL 18.1600 mL 45.4001 mL
5 mM 0.3632 mL 1.8160 mL 3.6320 mL 9.0800 mL
10 mM 0.1816 mL 0.9080 mL 1.8160 mL 4.5400 mL
15 mM 0.1211 mL 0.6053 mL 1.2107 mL 3.0267 mL
20 mM 0.0908 mL 0.4540 mL 0.9080 mL 2.2700 mL
25 mM 0.0726 mL 0.3632 mL 0.7264 mL 1.8160 mL
30 mM 0.0605 mL 0.3027 mL 0.6053 mL 1.5133 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telomeric G4s ligand 13047091-81-3G-quadruplexDNA/RNA SynthesisApoptosistelomeric G-quadruplex ligandDNA damageR-loop formationapoptosiscell cycle arrest in G2/M phaseInhibitorinhibitorinhibit

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