2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker
  4. Tesirine

Tesirine (GMP) (SG3249 (GMP)) 是 GMP 级别的 Tesirine (HY-128952)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Tesirine (SG3249) 是一种吡咯苯并二氮卓 (PBD) 二聚体，可用于合成抗体偶联活性分子 (ADC) 。PBD 二聚体是一种高效的 DNA 小沟交联剂，具有很强的细胞毒性。Tesirine 具有良好的疏水性和改进的共轭特性。SG3199 (HY-101161) 是 Tesirine 系列 ADC 的有效载荷的释放弹头。SG3199 在一组癌细胞系中保持皮摩尔活性。

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Tesirine

Tesirine Chemical Structure

CAS No. : 1595275-62-9

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Tesirine 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity[1][2].

IC50 & Target[1]

Pyrrolobenzodiazepines

 

体外研究
(In Vitro)

Tesirine (SG3199) (GMP) 是 ADC 有效载荷 Tesirine 的释放弹头组件。Tesirine 抑制 K562、NCIN87、BT474 和 SKBR3 癌细胞，IC50 分别为 150 pM、20 pM、1 nM 和 320 pM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tesirine 相关抗体:
分子量

1496.65

Formula

C75H101N9O23
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tesirine 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tesirine (GMP)1595275-62-9SG3249 (GMP)Drug-Linker Conjugates for ADCDNA Alkylator/Crosslinkercross-linkingPBDdimercytotoxicityantitumorDNAInhibitorinhibitorinhibit

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目录号：
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